p38丝裂原激活蛋白激酶在脑缺血预适应中的作用研究近况  

p38 mitogen activated protein kinase to adapt to the situation in the study of the interaction in the brain ischemia

作　　者：陈炜[1] 刘泰[1] 李丹 

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023 [2]广西桂平市中医医院,广西桂平537200

出　　处：《药学研究》2015年第6期349-352,共4页Journal of Pharmaceutical Research

基　　金：广西自然资金项目(No.2011GXNSFA018180);广西攻关项目(No.桂科攻11107009-1-11)

摘　　要：缺血预适应是机体对缺血性损伤的一种内源性保护机制。近来研究发现,p38丝裂原激活蛋白激酶(p38MAPK)的激活参与了脑缺血预适应的发生发展过程。关于p38MAPK在脑缺血预适应中的作用,报道的结果并不一致。本文就近十余年来p38MAPK在脑缺血预适应中的作用进展进行综述。Ischemic preconditioning on ischemic injury of the body is an endogenous protective mechanism. Recent findings,p38 mitogen activated protein kinase( p38MAPK) activation in the process of the occurrence and development of cerebral ischemia preconditioning. About the role of p38 MAPK in brain ischemia preconditioning,reported results were not consistent. This article reviewed the progress of p38 MAPK in cerebral ischemic preconditioning in recent ten years.

关 键 词：P38丝裂原激活蛋白激酶 信号通路 脑缺血预适应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]