氯氮平日剂量与精神分裂症患者稳态血药浓度相关性分析  

Correlation analysis between daily dose of clozapine and steady serum drug concentration in schizophrenia patients

作　　者：张文英[1] 刘利盛[1] 沈广虎[1] 

机构地区：[1]天津市安定医院,300222

出　　处：《四川精神卫生》2015年第3期239-240,共2页Sichuan Mental Health

摘　　要：目的探讨精神分裂症患者服用氯氮平日剂量与稳态血药浓度之间的关系,为指导临床合理用药提供参考。方法回顾分析服用氯氮平的精神分裂症患者病历,选取2013年6月-2014年6月在天津市安定医院住院的精神病患者,男性218例,女性157例。均采用高效液相色谱法检测住院患者血清氯氮平稳态血药浓度,并按日剂量分组,将其中位数进行等级相关性分析。结果氯氮平日剂量与稳态血药浓度呈正相关(男性组r=0.951,P<0.01;女性组r=0.983,P<0.01)。结论氯氮平稳态血药浓度与精神分裂症患者服药日剂量呈正相关。Objective To explore the relationship ketween daily dose of clozapine and steady serum drug concentration in pa=tients with schizophrenia,and to provide guidelines for rational application of clozapine in clinical practice. Methods Medical records of psychiatric patients with clozapine were researched retrospectively,select of hospitalized patients from June 2013 to June 2014 in Tianjin Anding Hospital,including male 218,female 157. Serum drug concentration of clozapine which was determined ky HPLC. Data was grouped according to the daily dose and analyzes the rand correlativity ketween the median and the daily dose. Results Steady se=rum drug concentration is direct proportion to daily dose,male patients(r=0. 951,P﹤0. 01),female patients(r=0. 983,P﹤0. 01). Conclusion Daily dose of clozapine is closely related with steady serum drug concentration,thereˊs a vast individual difference.

关 键 词：氯氮平 日剂量 稳态血药浓度 

分 类 号：R749[医药卫生—神经病学与精神病学]