SERPING1基因rs2511989多态性与年龄相关性黄斑变性相关性研究的Meta分析（英文）  

Geneticpolymorphism of SERPING1 rs2511989 and age-related macular degeneration: a Meta-analysis

作　　者：秦宇[1] 赵江月[1] 潘春树 何雪菲[3] 闵晓洁[1] 王明武[4] 阎启昌[1] 吴迪[1] 李晶[1] 吴欣蔚[1] 张劲松[1] 

机构地区：[1]中国医科大学附属第四医院眼科,中国医科大学眼科医院辽宁省晶状体学重点实验室,中国辽宁省沈阳市110005 [2]中国北京市解放军第二炮兵总医院放射线科,100088 [3]中国浙江省宁波市第二医院眼科,315000 [4]美国亚利桑那大学眼科与视觉科学院,85711-1824

出　　处：《国际眼科杂志》2015年第6期944-949,共6页International Eye Science

基　　金：国家自然科学基金项目(No.81270988);辽宁省高等学校科学研究一般项目(No.L2014305);中国医科大学附属第四医院青年创新发展基金项目(No.YB1217)~~

摘　　要：目的：探讨经典通路SERPING1基因rs2511989基因多态性与年龄相关性黄斑变性（age-related macular degeneration,AMD）的相关性。方法：检索中国学术期刊网（CNKI）、PubMed、Cochrane、Embase以及Web of Science数据库,使用随机效应模型,使用OR值及其95%可信区间评价SERPING1 rs2511989基因多态性与AMD易感性的关联程度,同时对入选文献异质性,敏感性以及发表偏倚等进行评估。结果：共纳入15项病例对照研究,收集8657例AMD患者,对照组5393例。各个遗传模型中均未发现SERPING1基因多态性与AMD发病具有相关性。（显性模型：OR=0.960,95%CI：0.918～1.003,P=0.009;隐性模型：OR=0.898,95%CI：0.791～1.019,P=0.035;共显性纯合模型：OR=0.881,95%CI：0.770～1.008,P=0.003;共显性杂合模型：OR=0.962,95%CI：0.917～1.010,P=0.050）。但进一步研究发现SERPING1基因多态性与新生血管型AMD显著相关。（显性模型：OR=0.691,95%CI：0.547～0.872;共显性纯合模型：OR=0.661,95%CI：0.450～0.971;共显性杂合模型：OR=0.754,95%CI：0.589～0.964）。亚组分析未发现种族与国家对rs2511989基因多态性与AMD有影响。结论：通常情况下SERPING1 rs2511989基因多态性与AMD无相关性,但在新生血管类型AMD可能与其存在相关性。期待更多研究来证实该假说。AIM： To explore the association between the polymorphism rs2511989 in the classical pathway geneSERPING1 （C1 inhibitor） and age-related macular degeneration （AMD）. METHODS： A random- effect Meta- analysis was performed. An electronic search was done in CNKI, PubMed, the Cochrane Collaboration＇s Database, Embase, and the ISl Web of Knowledge. Odds ratios （OR） and their 95% confidence interval （CI） were calculated to assess the strength of association between SERPING1 rs2511989 polymorphism and AMD susceptibility. Heterogeneity, sensitivity analysis and publication bias were also tested. RESULTS： A total of 15 case-control studies with 8657 cases and 5393 controls were finally included in this Meta-analysis. There was no significant association between SERPING1 and AMD in all genetic models. （Dominant model= OR=0. 960, 95%CI.. 0. 918-1. 003, P=0. 009; recessive model, OR = 0. 898, 95% CI. 0. 791 -1. 019, P= 0.035; homozygote model= OR = 0. 881, 95% CI. 0. 770- 1. 008, P= 0.003 ; heterozygote model.. OR = 0. 962, 95% CI. 0.917- 1. 010, P = 0. 050）. However, the associations between SERPING1 and neovascular AMD were significant in three models （dominant model： OR = 0. 691, 95% CI： 0. 547- 0. 872; homozygote model： OR = 0. 661, 95% CI. 0. 450- 0. 971 ; heterozygote model. OR = 0. 754, 95% CI： 0. 589-0.964）. Subgroup analysis by ethnicity and country did not find significant association between rs2511989 polymorphism and AMD susceptibility. CONCLUSION= SERPING1 rs2511989 does not associates with AMD generally but may associate with neovascular AMD. More studies are required to verify the hypothesis.

关 键 词：年龄相关性黄斑变性 SERPING1 基因多态性 META分析 

分 类 号：R774.5[医药卫生—眼科]