光学相干断层扫描黄斑厚度与强直性脊柱炎并发前葡萄膜炎严重性的相关分析  

Correlation analysis of macular thickness by optical coherence tomography and disease severity in patients with ankylosing spondylitis combined with anterior uveitis

作　　者：宋国祥[1] 黄进贤[2] 邓亚玲[1] 梁张翼 赵视野 

机构地区：[1]深圳市第三人民医院眼科,广东省深圳市518000 [2]香港大学深圳医院风湿科,广东省深圳市518000

出　　处：《眼科新进展》2015年第6期539-541,共3页Recent Advances in Ophthalmology

基　　金：国家自然科学基金青年项目(编号:81301529)~~

摘　　要：目的探讨强直性脊柱炎（ankylosing spondylitis,AS）并发前葡萄膜炎患者黄斑病变和疾病严重程度的相互关系。方法回顾性分析50例（50眼）AS并发前葡萄膜炎患者裂隙灯下眼前段病变与红细胞沉降率（erythrocyte sedimentation rate,ESR）、C反应蛋白（C reactive protein,CRP）以及最佳矫正视力（best corrected visual acuity,BCVA）和黄斑病变情况。前葡萄膜炎严重程度根据改良的EIU临床标准判定,采用光学相干断层扫描（opti-cal coherence tomography,OCT）测量黄斑区厚度。结果 50例AS患者中,前葡萄膜炎均为单眼发作,EIU评分为2~10分,患眼黄斑厚度为（235.36±12.12）μm,健眼为（190.02±8.56）μm,二者比较有显著性差异（t=21.60,P〈0.001）。进一步分析表明,葡萄膜炎EIU评分与ESR（r=0.870,P〈0.001）和CRP（r=0.699,P〈0.001）、BCVA（r=-0.935,P〈0.001）以及黄斑厚度均密切相关（r=0.662,P〈0.001）。结论 AS患者前葡萄膜炎可累及眼后段,出现患眼黄斑增厚及水肿,且与疾病严重程度相关。Objeetive To investigate the relationship between macuiar changes and disease severity in patients with ankylosing spondylitis （AS） combined with anteri- or uveitis. Methods Anterior changes in 50 patients （50 eyes） with AS combined with anterior uveitis were evaluated by slit lamp, erythrocyte sedimentation rate （ ESR）, C-reactive protein （ CRP）, best corrected visual acuity （BCVA） and macuiar changes were retrospectively analyzed. A modified endotoxin-induced uveitis （EIU） clinical standard was used for uveitis grading. Macular thickening was measured by optical co- herence tomography （OCT）. Results Among the 50 patients with AS,all the compli- cation of anterior uveitis were attacked with a single eye. EIU uveitis grading scored 2 - 10. The macuiar thickness of the affected eye （235. 36 ± 12. 12 ） μm was significantly thicker than that of the control eye （ 190.02 ± 8.55） μm （ t = 21.60 ,P 〈 0. 001 ）. Further analysis showed that, the EIU uveitis grading score were correlated with ESR （ r = 0. 870 ,P 〈 0.001 ）, CRP （ r = 0.699 ,P 〈 0.001 ）, BCVA （ r = - 0.935 ,P 〈 0.001 ） and mac- uiar thickness （ r = 0.552 ,P 〈 0.001 ）. Conclusion In patients with AS, anterior uvei- tis can affect the posterior portion of the eye, which manifested as macuiar thickening and edema, and is correlated with degree of disease severity.

关 键 词：前葡萄膜炎 强直性脊柱炎 光学相干断层扫描 

分 类 号：R774.5[医药卫生—眼科]