胃腺癌中EZH2、Akt蛋白的表达及意义  

Expressions and clinical significance of EZH2,Akt proteins in human gastric adenocarcinoma

作　　者：杨德生[1] 康玉华[1] 李福春[2] 孙珠蕾[3] 张卉[1] 索智敏[1] 

机构地区：[1]河南大学淮河医院消化内科,开封475000 [2]河南大学淮河医院超声科,开封475000 [3]河南大学淮河医院病理科,开封475000

出　　处：《现代免疫学》2015年第3期205-209,共5页Current Immunology

基　　金：开封市科技攻关计划项目(110341)

摘　　要：研究果蝇zeste基因增强子同源物2(enhancer of zeste homolog 2,EZH2)及Akt蛋白在胃腺癌中的表达及与其临床意义。方法应用S-P免疫组化技术检测73例胃腺癌及其相应的癌旁正常组织中EZH2和Akt蛋白的表达。73例胃腺癌组织中EZH2、Akt蛋白的阳性表达率67.1%(49/73)、61.6%(45/73)均高于癌旁正常组织5.5%(4/73)、10.4%(7/73),差异具统计学意义(P<0.05);EZH2的表达与肿瘤分化程度、浸润深度、淋巴结转移及临床分期相关,有统计学意义(P<0.05);Akt蛋白的表达与淋巴结转移相关有统计学意义(P<0.05)。EZH2与Akt蛋白在胃腺癌组织中的表达呈负相关关系(rs=-0.252,P<0.05)。EZH2与Akt在胃腺癌的发生发展中发挥重要作用,且EZH2的调控可能与Akt的活化有关。To investigate the relationship and clinical significance between the expressions of EZH2 and Akt proteins in gastric adenocarcinoma. S-P immunohistochemistry was used to detect the expression of EZH2 and Akt proteins in pathological tissue with 73 cases with gastric adenocarcinoma and tumor-adjacent normal gastric tissue. The positive expression rates of EZH2 and Akt proteins in 73 cases with gastric adenocarcinoma tissue 67.1 % （49/73）, 61.6% （45/73） respectively, were significantly different from the positive expression rates of tumor-adjacent normal gastric tissues 5.5 % （4/73）, 10.4% （7/73） respectively （P〈0.05）; The expression of EZH2 was significantly correlated to differentiation degree, infiltrative depth, TNM stage, lymph node metastasis （P〈0.05）and the expression of Akt protein was significantly correlated to lymph node metastasis （P〈 0.05）. There was negative correlation between the expression of EZH2 and Akt proteins in gastric adenocarcinoma and the value of spearman coefficient correlation were 0. 252 （P〈0.05）. EZH2 and Akt may play an important role in tumorigenesis and tumor progression, and EZH2 was regulated by the activation of Akt.

关 键 词：果蝇zeste基因增强子同源物2 胃腺癌 AKT 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]