维生素D受体ApaI和FokI位点基因多态性和种植体周围炎的相关性研究  

Investigation on the relationship between gene polymorphisms of vitamin D receptor(Apa I, Fok I) and peri-implantitis

作　　者：刘琼[1] 黄建生[1] 卿玲[1] 谢宇[1] 张宇婕[1] 

机构地区：[1]南方医科大学附属口腔医院.广东省口腔医院特诊中心,广州510280

出　　处：《现代口腔医学杂志》2015年第3期153-156,共4页Journal of Modern Stomatology

摘　　要：目的探讨维生素D受体(vitamin D receptor,VDR)Apa I和Fok I位点基因多态性和种植体周围炎是否具有相关性。方法采用病例对照试验设计,种植体周围炎组及健康对照组各65例,应用聚合酶链反应-限制性内切酶片段长度多态性分析方法研究2组VDR Apa I和Fok I位点的基因型以及等位基因分布特点,并探讨其与种植体周围炎的相关性。结果两组VDR基因Apa I位点和Fok I位点各基因型以及等位基因频率分布差异无统计学意义。结论排除吸烟、牙周炎病史等影响因素后,尚未发现VDR Apa I位点和Fok I位点基因多态性在种植体周围炎发生中发挥着重要作用。Objective To investigate the association between the genetic polymorphism of vitamin D receptor （ApaI, FokI） and peri-implantitis. Methods The subjects were divided into peri-implantitis group and control healthy group, with 65 cases for each group. The case-control trial was used in this study. Polymerase chain reaction-restriction fragment length polymorphism was applied to analyze the genotype of vitamin D receptor （ApaI, FokI）, the characteristics of distribution, and correlation with peri-implantitis. Results There were no siginificant differences in genotypes or allele frequencies of VDR genotypes（ApaI, FokI） between peri-implantitis groups and control group. Conclusion VDR genetic polymorphism （ApaI, FokI） do not paly important roles in the development of peri-implantitis excluding some influence factors, such as smoking and periodontitis.

关 键 词：维生素D受体 基因多态性 种植体周围炎 

分 类 号：R783.6[医药卫生—口腔医学]