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机构地区:[1]解放军251医院皮肤科,河北张家口075000 [2]河北北方学院附属一院病理科,张家口075000
出 处:《中国麻风皮肤病杂志》2015年第5期276-278,281,共4页China Journal of Leprosy and Skin Diseases
摘 要:目的:检测CD10在毛囊皮脂腺囊性错构瘤(FSCH)中的表达。方法:采用免疫组化法检测6例FSCH、10例皮脂腺痣、10例皮脂腺增生症和10例正常皮肤的石蜡组织中CD10的表达。结果:CD10在FSCH皮脂腺结构中呈阳性高表达(100%),与皮脂腺痣(20%)和皮脂腺增生症(10%)相比,差异均具有统计学意义(P<0.05);CD10在FSCH间叶组织中呈低表达(20%),与皮脂腺痣(100%)和皮脂腺增生症(100%)相比同样具有统计学意义(P<0.05)。结论:CD10表达可作为鉴别FSCH与皮脂腺痣和皮脂腺增生的一个指标。Objective: To detect the expression of CD10 in folliculosebaceous cystic hamartoma (FSCH). Methods: The expression of CD10 in paraffin-embedded samples of FSCH (6 patients), sebaceous nevus (10 patients), sebaceous hyperplasia (10 patients) and normal skin (10 persons ) was detected with immu- nohistochemistry. Results: The positivity rate of CD10 in the sebaceous gland structure of FSCH was 100%, which was higher than 20% in sebaceous nevus (20%) and sebaceous hyperplasia (10%) (P〈0.05). The positivity rate of CD10 in the mesenchymal tissue of FSCH was 20%, which was lower than 100% in seba- ceous nevus and in sebaceous hyperplasia (P〈0.05). Conclusion: The expression of CD10 is a potential marker in differential diagnosis of FSCH, sebaceous nevus and sebaceous hyperplasia.
关 键 词:毛囊皮脂腺囊性错构瘤 皮脂腺痣 皮脂腺增生症 CD10 免疫组化
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