新疆地区宫颈癌HLA-DQB1等位基因与临床特征及近期疗效相关性研究  

Correlation between HLA-DQB1 allele and short-term curative effect and the clinical characteristics about cervical cancer in Xinjiang

作　　者：姜鹏[1] 古丽娜.库尔班 王若峥[1,2,3] 

机构地区：[1]新疆医科大学附属肿瘤医院放疗中心,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院妇瘤放疗科,新疆乌鲁木齐830011 [3]新疆肿瘤学重点实验室,新疆乌鲁木齐830011

出　　处：《中华肿瘤防治杂志》2015年第12期978-983,共6页Chinese Journal of Cancer Prevention and Treatment

基　　金：科技部国际合作项目(2012DFA31560)

摘　　要：目的分析新疆地区维吾尔族与汉族宫颈癌患者HLA-DQB1等位基因频率差异,探索HLA-DQB1与临床特征和近期疗效之间的关系。方法纳入2013-05-1-2013-12-30新疆医科大学附属肿瘤医院收治的68例维吾尔族及20例汉族宫颈癌患者,采集外周血并分离提取DNA,检测HLA-DQB1基因。比较不同临床特征和近期疗效之间基因频率的差异。结果维吾尔族HLA-DQB1*03基因频率为33.1%,低于汉族的55.0%,差异有统计学意义,P<0.05;维吾尔族HLA-DQB1*02基因频率为30.9%,高于汉族的10.0%,差异有统计学意义,P<0.05。维吾尔族HLA-DQB1*04、HLA-DQB1*05和HLA-DQB1*06等位基因频率分别为5.9%、8.8%和21.3%,汉族HLA-DQB1*04、HLA-DQB1*05和HLA-DQB1*06等位基因频率分别为5.0%、12.5%和17.5%,差异均无统计学意义,P>0.05。HLA-DQB1各等位基因频率在不同年龄分组及HPV16表达分组之间比较,差异均无统计学意义,P>0.05。治疗有效(CR+PR)患者HLA-DQB1*03基因频率为42.9%,高于治疗无效(SD+PD)患者的26.0%,差异有统计学意义,P<0.05。其余各等位基因频率在两组之间比较差异均无统计学意义,P>0.05。结论新疆地区维吾尔族宫颈癌患者HLA-DQB1*03基因频率低于文献报道,HLA-DQB1*02基因频率高于文献报道;HPV16阳性患者HLA-DQB1*04基因频率高于HPV16阴性患者;治疗有效患者HLA-DQB1*03等位基因频率高于治疗无效患者;HLA-DQB1*03等位基因可能与近期疗效有关。OBJECTIVE To analyze the HLA-DQB1 allele frequency difference between uighurs and han Chinese patients with cervical cancer in xinjiang region,and explore the relationship between HLA-DQB1 gene and clinical features or the recent curative effect.METHODS Sixty-eight cases of Uighur and 20 cases of han nationality patients with cervical cancer were included.They were treated in Affiliated Tumor Hospital of Xinjiang Medical University from May 1to December 30,2013.Peripheral blood was collected,DNA was extracted,and HLA-DQB1 genes were detected.The gene frequencies were compared between different clinical features or different recent curative effects.RESULTS HLADQB1＊03gene frequency was 33.1%in Uighur.It was lower than 55.0%in Han nationality.The difference was statistically significant（P〈0.05）.HLA-DQB1＊02gene frequency was 30.9%in Uighur,which was higher than 10.0%in Han nationality.The difference was statistically significant（P〈0.05）.HLA-DQB1＊04,05 and 06allele frequencies were5.9%,8.8% and 21.3%respectively in Uighur,but frequencies were 5.0%,12.5% and 17.5%respectively in Han nationality.There were no statistically significant difference（P〉0.05）.Comparison of HLA-DQB1 allele frequencies in different groups of age and groups of HPV16 expression,there were no statistically significant differences（P〈0.05）.HLADQB1＊03gene frequency was 42.9%in effective treatment group（CR＋PR）,which was higher than 26.0%in invalid treatment group（SD＋PD）,and the difference was statistically significant（P〈0.05）.To compare the rest of the allele frequency between the two groups,the difference had no statistical difference（P〉0.05）.CONCLUSIONS HLA-DQB1＊03gene frequency for patients with cervical cancer in xinjiang region is lower than that of literature reported,but HLADQB＊02gene frequency is higher.HLA-DQB1＊04gene frequency in HPV16 positive patients was higher than that in HPV16 negative patients.HLA-DQB1＊03allele frequency in effective treatment patients is higher than that

关 键 词：宫颈肿瘤 HLA-DQB1基因 临床特征 近期疗效 

分 类 号：R737.33[医药卫生—肿瘤]