18F-FDG PET-CT显像对胸腺上皮性肿瘤世界卫生组织（WHO）组织学分型的预测价值分析  

Value of 18F-FDG PET-CT in predicting the WHO grade of malignancy in thymic epithelial tumors

作　　者：刘辰[1] 孙利[2] 李囡[1] 王雪鹃[1] 于江媛[1] 林保和[1] 黄川[3] 杨志[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科恶性肿瘤发病机制及转化研究教育部重点实验室,100142 [2]北京大学肿瘤医院病理科,100142 [3]北京大学肿瘤医院胸外科,100142

出　　处：《肿瘤研究与临床》2015年第5期294-297,309,共5页Cancer Research and Clinic

基　　金：国家自然科学基金（81172083）

摘　　要：目的 探讨术前18F-脱氧葡萄糖（18F-FDG） PET-CT显像对胸腺上皮性肿瘤世界卫生组织（WHO）组织学简化分型的预测价值.方法 45例经病理证实的胸腺上皮性肿瘤患者,根据WHO简化组织学分型法分为低危组及高危组,对其18F-FDG PET-CT影像进行回顾性分析.采用Spearman法分析PET-CT的半定量指标与胸腺肿瘤WHO简化分型之间的相关性,并利用单因素Logistic回归分析联合受试者工作曲线（ROC曲线）评价PET-CT预测WHO简化分型的诊断效能.结果 45例胸腺上皮性肿瘤患者中,低危组10例（22.2％）,高危组35例（77.8％）.18F-FDG PET-CT显像的最大标准摄取值（SUVmax）、SUVmax与肿瘤最大径比值（SUVmax/T）与胸腺上皮性肿瘤WHO简化分型相关（r值分别为0.577和0.621,均P＜ 0.000 1）;SUVmax、SUVmax/T预测胸腺上皮性肿瘤组织学分型的诊断效能均较高（ROC曲线下面积分别为0.888和0.917,均P＜ 0.000 1）.结论 18F-FDG PET-CT显像与胸腺上皮性肿瘤组织学WHO简化分型相关,对胸腺上皮性肿瘤的病理恶性度分级有预测价值.Objective To investigate the value of 18F-FDG PET-CT in predicting the simplified WHO grade of malignancy in thymic epithelial tumors.Methods The 18F-FDG PET-CT imaging of forty-five patients with pathologically proven thymic epithelial tumors was analyzed retrospectively.The patients were subdivided into a low-risk group and a high-risk group based on the simplified WHO histological classification.Spearman rank correlation analysis was used to determine the relation between parameters of PET-CT and simplified WHO histological classification.An univariate logistic regression analysis and ROC curve were performed for assessing the ability of 18F-FDG PET-CT as a predictor of the simplified WHO classification.Results There were ten patients classified into low-risk group,and thirty-five patients classified into high-risk group.Both SUVmax and SUVmax / T showed significant relationship with patients subgroup （Spearman correlation coefficients were 0.577 and 0.621,respectively,P 〈 0.000 1）.The SUVmax and SUVmax / T were found to be predictive factors that were useful to distinguish high-risk tumor from lowrisk tumor （area under the ROC curve were 0.888 and 0.917,respectively,P 〈 0.000 1）.Conclusions A significant relationship is observed between 18F-FDG PET-CT findings and histological WHO classification of thymic epithelial tumors.PET-CT may be useful for predicting the grad of malignancy in thymic epithelial tumors.

关 键 词：胸腺上皮性肿瘤 组织学分型 氟脱氧葡萄糖F18 正电子发射断层显像术 

分 类 号：R736.3[医药卫生—肿瘤]