白内障术后非甾类抗炎药物单独抗炎作用的有效性与安全性研究  

Efficacy and safety of bromfenac sodium ophthalmic solution as anti-inflammatory agent after cataract phacoemusification

作　　者：沈婷[1] 池新昌[1] 郑青青[1] 刘七平 洪朝阳[1] 

机构地区：[1]浙江省人民医院眼科,杭州310014

出　　处：《浙江医学》2015年第10期840-842,853,共4页Zhejiang Medical Journal

摘　　要：目的探讨白内障超声乳化术后单独局部应用非甾类抗炎药物0.1%溴芬酸钠的有效性、安全性和耐受性。方法选取年龄相关性白内障患者64例(64眼)行常规超声乳化白内障摘除联合后房型人工晶体植入术,分为溴芬酸钠组32例(32眼)和激素组(对照组)32例(32眼)。溴芬酸钠组术后第1天起予0.1%溴芬酸钠水合物滴眼液2次/d,持续4周;对照组术后第1天起予典必殊滴眼液4次/d,使用1周后改为0.1%氟美瞳滴眼液4次/d续用至4周。观察并记录两组患者术前及术后第1天、1周、2周、1个月的视力、眼压、炎症症状评分、眼部体征评分及安全性评价评分。结果溴芬酸钠组术后视力恢复情况与对照组比较无统计学差异。术后第1周时溴芬酸钠组眼压明显低于对照组(P<0.05),第2、4周眼压值仍低于对照组,但无统计学差异(P>0 05)。在炎症症状、眼部体征评分与安全性评价评分上,溴芬酸钠组与对照组均无统计学差异(P>0.05)。结论非甾类抗炎药物溴芬酸钠用于白内障术后抗炎有效、安全,无明显不耐受,能一定程度上代替激素作为围手术期用药。Objective To evaluate the efficacy and safety of 0. 1% bromfenac sodium ophthalmic solution as anti-inflammatory agent after cataract phacoemusification. Methods Sixty four patientswith aged related cataract （64 eyes） receiving phacoemulsification were enrolled, and randomized to receive 0.1% bromfenac sodium solution twice daily（bromfenac group, 32eyes） or glucocorticoid 4 times daily （control group, 32 eyes） for one month. The visual acurity, intraocular pressure, postoperative inflammation scores and safety were recorded and compared between two groups. Results There was no significant difference in the recovery of visual acurity, evaluation scores of postoperative inflammation and safety between two groups. Intraocular pressure at week1 after surgery was lower in bromfenac sodium group than that in control group（P〈0.05）. Conclusion Bromfenac sodium is effective and safe as the only anti-inflammatory drug after cataract phacoemusification, and it may displace glucocorticoids perioperativly.

关 键 词：溴芬酸钠 糖皮质激素 白内障 非甾类抗炎药物 

分 类 号：R779.66[医药卫生—眼科]