Synthesis and Crystal Structure of (S)-N-(2-oxoazepan-3-yl) biphenyl-4-carboxamide  

作　　者：方正 陈克涛 李小林 曾文波 郭凯 

机构地区：[1]School of Pharmaceutical Sciences,Nanjing Tech. University [2]College of Biotechnology and Pharmaceutical Engineering ,Nanjing Tech. University

出　　处：《Chinese Journal of Structural Chemistry》2015年第1期82-86,共5页结构化学（英文）

基　　金：Supported by the National Key Basic Research Program of China(973 Program,2012CB725204 and 2012CB721104);the Natural Science Foundation of Jiangsu Province(No.BK20130913);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1066)

摘　　要：The title compound（S）-N-（2-oxoazepan-3-yl）biphenyl-4-carboxamide（C19H20N2O2, Mr = 308.37） was synthesized by the reaction of（S）-α-amino-∑-caprolactam with 4-phenyl-benzoyl chloride. Its chemical structure was determined by 1H NMR, 13 C NMR, H RMS and X-ray single-crystal diffraction. The crystal belongs to the triclinic system, space group P1 with a = 8.2650（17）, b = 13.774（3）, c = 15.109（3） A, β = 90.20（3）o, V = 1645.6（6） A3, Z = 4, Dc = 1.245 g/cm3, μ = 0.081 mm-1, F（000） = 656, R = 0.0756 and w R = 0.1491 for 5964 observed reflections with I 〉 2σ（I）. The title compound was also used to prepare polyamide.The title compound（S）-N-（2-oxoazepan-3-yl）biphenyl-4-carboxamide（C19H20N2O2, Mr = 308.37） was synthesized by the reaction of（S）-α-amino-∑-caprolactam with 4-phenyl-benzoyl chloride. Its chemical structure was determined by 1H NMR, 13 C NMR, H RMS and X-ray single-crystal diffraction. The crystal belongs to the triclinic system, space group P1 with a = 8.2650（17）, b = 13.774（3）, c = 15.109（3） A, β = 90.20（3）o, V = 1645.6（6） A3, Z = 4, Dc = 1.245 g/cm3, μ = 0.081 mm-1, F（000） = 656, R = 0.0756 and w R = 0.1491 for 5964 observed reflections with I 〉 2σ（I）. The title compound was also used to prepare polyamide.

关 键 词：LYSINE POLYAMIDE CAPROLACTAM crystal structure 

分 类 号：TQ323.7[化学工程—合成树脂塑料工业] O76[理学—晶体学]