LYSINE

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Epigenetic regulation of cardiac tissue development by lysine lactylation
《hLife》2025年第2期82-97,共16页Xiaodong Luan Runhua Du Gengchen Su Cong Yan Xuelian Ren Kaide Ju Ye Jin Yang An Dan Guo Zhuang Tian He Huang Shuyang Zhang 
funded by National Key Research and Development Program Funding(2023YFC3605504,to X.L);National High-Level Hospital Clinical Research Funding(2022-PUMCHB-098,to S.Z);National Natural Science Foundation of China(22277125 and 92253306 to H.H.);Natural Science Foundation of Shanghai(23ZR1474600 to H.H.);Shanghai Municipal Science and Technology Major Project(to H.H.);Tsinghua-Peking Center for Life Sciences(045-61020100123,to S.Z.).
Heart disease stands as the foremost global cause of mortality.In rodents,the heart possesses the remarkable ability for cardiac regeneration within the first 7 days post-birth.Furthermore,the transition to an oxygen-...
关键词：cardiac tissue development multi-omics analysis H4K12la gene expression regulation 
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
《Cell Research》2025年第2期97-116,共20页Qihang Zhao Qiang Wang Qinghua Yao Zhengdong Yang Wenfang Li Xiaojie Cheng Yingling Wen Rong Chen Junfang Xu Xuanying Wang Dexiang Qin Shuyang Zhu Liujie He Nan Li Yanfeng Wu Yizhi Yu Xuetao Cao Pin Wang 
supported by the National Natural Science Foundation of China(92169116,81971499,31722019,82070765,82388201,82303198);Key Project of Natural Science Foundation of Zhejiang Province(LZ20H290001);Shanghai Shuguang Program(19SG33).
Immunometabolism is critical in the regulation of immunity and inflammation;however,the mechanism of preventing aberrant activation-induced immunopathology remains largely unclear.Here,we report that glyoxalase II(GLO...
关键词：INFLAMMATORY INFLAMMATION METABOLISM 
Center-concave nanosheets of core-shell WO3@Prussian blue based handheld microchip-devices for ultrasensitive lysine determination
《Chinese Journal of Chemical Engineering》2024年第12期21-29,共9页Huaiyu Song Meiyue Wang Tao Liu Zhengkun Liu Ying Xie Zhenyu Chu Wanqin Jin 
financially supported by the National Key Research and Development Program of China(2021YFC2103300);the National Natural Science Foundation of China Youth Found(22308154 and 22108120);the Natural Science Foundation of Jiangsu Province(BK20231518 and BK20210549).
Lysine is one of the essential amino acids for human body,and its imbalance is a major cause to anemia,aging process,leukemia cell proliferation and tumor growth.Therefore,its monitoring is dominative to the preventio...
关键词：Center-concave nanosheets Core-shell WO3@PB Lysine detection Blood analysis 
Targeting the lysine lactylome for the treatment of glioma
《Cancer Biology & Medicine》2024年第12期1095-1099,共5页Di Wang Guanzhang Li Tao Jiang Wei Zhang 
supported by the National Natural Science Foundation of China(Grant No.82072768);Youth Beijing Scholar(Grant No.055);The Outstanding Young Scientist Program of Beijing Universities(Grant No.JWZQ20240101026);Beijing Municipal Health Commission Research Ward Excellence Clinical Research Program(Grant No.BRWEP2024W032040200).
The anomalous activation of glycolysis and subsequent accumulation of L-lactate under aerobic conditions,known as the Warburg effect,are prominent metabolic hallmarks of cancer1.Extensive research has revealed that la...
关键词：GLIOMA TREATMENT subsequent 
Pre-transplantation levels of lysine(K)-specific methyltransferase 2A(KMT2A)partial tandem duplications can predict relapse of acute myeloid leukemia patients following haploidentical donor hematopoietic stem cell transplantation
《Blood Science》2024年第4期52-59,共8页Dao-Xing Deng Xiao-Hang Ma Ze-Hua Wu Xiao-Hui Zhang Lan-Ping Xu Yu Wang Chen-Hua Yan Huan Chen Yu-Hong Chen Wei Han Feng-Rong Wang Jing-Zhi Wang Xiao-Jun Huang Xiao-Su Zhao Xiao-Dong Mo 
supported by the National Key Research and Development Program of China(2021YFC2500300,2022YFC2502606);the Grants from the Beijing Municipal Science and Technology Commission(Z221100007422008);Major Program of the National Natural Science Foundation of China(82293630,82293633);CAMS Innovation Fund for Medical Sciences(2022-I2M-C&T-B-121,2023-I2MC&T-B-123);Peking University People’s Hospital Research and Development Funds(RD2023-08);Tongzhou District Distinguished Young Scholars(JCQN2023009);the Fundamental Research Funds for the Central Universities。
We aimed to identify dynamic changes of lysine(K)-specific methyltransferase 2A partial tandem duplications(KMT2A-PTD)before and after haploidentical donor hematopoietic stem cell transplantation(HID HSCT)and explore ...
关键词：Acute myeloid leukemia Allogeneic hematopoietic stem cell transplantation HAPLOIDENTICAL KMT2A-PTD RELAPSE 
Improving Okra Performance:Biostimulants and their Influence on Yield,Quality,Physiology,and Nutrient Composition
《Phyton-International Journal of Experimental Botany》2024年第12期3531-3548,共18页Qurat-Ul-Ain Raza Abdur Rehim Muhammad Amjad Bashir Mingzheng Duan Yucong Geng Abdulwahed Fahad Alrefaei 
the Researchers Supporting Project(no.RSP2025R218),King Saud University,Riyadh,Saudi Arabia.
Chemical fertilizers have contributed to improving crop production and coping with food safety challenges,but their excessive application in agriculture has resulted in soil and environmental problems.The present stud...
关键词：Aspartic acid GLYCINE LYSINE SOIL vitamin B 
Effects and interactions of dietary lysine and apparent nitrogen corrected metabolizable energy on yellow-feathered broiler breeder hens
《Journal of Animal Science and Biotechnology》2024年第6期2467-2482,共16页Yibing Wang Qin Wang Xiangtian Yao Zhongyong Gou Xiajing Lin Qili Luo Shouqun Jiang 
financially supported by China Agriculture Research System of MOF and MARA(CARS-41);the National Key R&D Project(2021YFD1300404);the Natural Science Foundation from Guangdong Province(2022A1515012069);the Science and Technology Plan Project of Guangzhou(SL2022A04J00940,2024E04J0562);the Science and Technology Program of Guangdong Academy of Agricultural Sciences(R2023PY-QY012,R2021YJ-YB3012),P.R.China。
Background Dietary lysine and apparent nitrogen-corrected metabolizable energy(AMEn)are two key variables affecting the production of bre eder hens.In this study,the effe cts and interactions of lysine and AMEn on yel...
关键词：Breeder hens Egg quality LYSINE Metabolizable energy Productive performance Reproductive traits 
Role of lysine-specific demethylase 1 in immunotherapy of gastric cancer:An update
《Chinese Journal of Cancer Research》2024年第6期669-682,共14页Yongjing Ren Yanan Gong Huan Zhao Duo You Zhifei Li Sai-Qi Wang Xiaobing Chen 
supported by Natural Science Foundation of Henan Province(No.232300421119);Henan Medical Science and Technique Foundation of Henan Province(No.SBGJ202301004);National Natural Science Foundation of China(No.82103560);Medical Science and Technique Foundation of Henan Province(No.SBGJ202302029);Young and Middle-aged Health Science and Technology Innovation Talent Training Program of Henan Province(No.YXKC2022048);Postdoctoral Research Funding Project of Henan Province(Postdoctoral No.339552)。
Gastric cancer(GC)ranks 3rd in incidence rate and mortality rate among malignant tumors in China,and the age-standardized five-year net survival rate of patients with GC was 35.9%from 2010 to 2014.The tumor immune mic...
关键词：LSD1 immune cells gastric cancer IMMUNOTHERAPY 
Protein lysine crotonylation in cellular processions and disease associations
《Genes & Diseases》2024年第5期219-235,共17页Hongling Zhao Yang Han Pingkun Zhou Hua Guan Shanshan Gao 
the National Natural Science Foundation of China(No.82173466).
Protein lysine crotonylation(Kcr)is one conserved form of posttranslational modifications of proteins,which plays an important role in a series of cellular physiological and pathological processes.Lysine e-amino group...
关键词：Cell biology DISEASE Lysine crotonylation Posttranslational modification Therapeutic target 
Effects of improved amino acid balance diet on lysine mammary utilization, whole body protein turnover and muscle protein breakdown on lactating sows
《Journal of Animal Science and Biotechnology》2024年第5期2031-2043,共13页Sai Zhang Juan C.Marini Vengai Mavangira Andrew Claude Julie Moore Mahmoud A.Mohammad Nathalie L.Trottier 
financially supported by funds from the USDA-NIFA(award number 2014-67015-21832)。
Background The study objective was to test the hypothesis that low crude protein(CP)diet with crystalline amino acids(CAA)supplementation improves Lys utilization efficiency for milk production and reduces protein tur...
关键词：Amino acid Efficiency Lactating sows Protein breakdown Protein turnover Reduced protein diet 
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