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作 者:Yongjing Ren Yanan Gong Huan Zhao Duo You Zhifei Li Sai-Qi Wang Xiaobing Chen
机构地区:[1]Department of Oncology,the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer and Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer,Zhengzhou 450008,China [2]Chinese Medicine Academy of Chinese Medicine sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China
出 处:《Chinese Journal of Cancer Research》2024年第6期669-682,共14页中国癌症研究(英文版)
基 金:supported by Natural Science Foundation of Henan Province(No.232300421119);Henan Medical Science and Technique Foundation of Henan Province(No.SBGJ202301004);National Natural Science Foundation of China(No.82103560);Medical Science and Technique Foundation of Henan Province(No.SBGJ202302029);Young and Middle-aged Health Science and Technology Innovation Talent Training Program of Henan Province(No.YXKC2022048);Postdoctoral Research Funding Project of Henan Province(Postdoctoral No.339552)。
摘 要:Gastric cancer(GC)ranks 3rd in incidence rate and mortality rate among malignant tumors in China,and the age-standardized five-year net survival rate of patients with GC was 35.9%from 2010 to 2014.The tumor immune microenvironment(TIME),which includes T cells,macrophages,natural killer(NK)cells and B cells,significantly affects tumor progression,immunosuppression and drug resistance in patients with GC.In recent years,immunotherapy has become the first-line or second-line treatment for GC.Lysine-specific demethylase 1(LSD1,also known as KDM1A)was the first identified human histone demethylase,and high expression of LSD1 in GC is closely related to the dysfunction of the above types of immune cells.Therefore,LSD1 inhibitors could regulate the cytotoxic effects of immune cells against tumor cells through a variety of mechanisms to control tumor progression.In this review,we discuss the effects of LSD1 inhibitors on immune cells in GC and propose LSD1 as a new potential target for immunotherapy in GC.
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