Protein lysine crotonylation in cellular processions and disease associations  

作　　者：Hongling Zhao Yang Han Pingkun Zhou Hua Guan Shanshan Gao 

机构地区：[1]Beijing Key Laboratory for Radiobiology,Beijing Institute of Radiation Medicine,Beijing 100850,China

出　　处：《Genes & Diseases》2024年第5期219-235,共17页基因与疾病（英文）

基　　金：the National Natural Science Foundation of China(No.82173466).

摘　　要：Protein lysine crotonylation(Kcr)is one conserved form of posttranslational modifications of proteins,which plays an important role in a series of cellular physiological and pathological processes.Lysine e-amino groups are the primary sites of such modification,resulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these residues.High levels of Kcr modifications have been identified on both histone and non-histone proteins.The present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discussion of the mechanisms whereby Kcr modification governs a range of biological processes.In addition,given the importance of protein Kcr modification in disease onset and progression,the potential viability of Kcr regulators as therapeutic targets is elucidated.

关 键 词：Cell biology DISEASE Lysine crotonylation Posttranslational modification Therapeutic target 

分 类 号：Q51[生物学—生物化学]