自体外周血干细胞移植治疗失代偿期肝硬化  

Autologous peripheral stem cell transplantation in the treatment of decompensated hepatic cirrhosis

作　　者：李梅[1] 党双锁[1] 田长印[1] 翟嵩[1] 贾晓黎[1] 赵文学[1] 张欣[1] 潘国英[1] 王媛[1] 高宁[1] 

机构地区：[1]西安交通大学医学院第二附属医院感染科,710004

出　　处：《肝脏》2015年第4期269-272,共4页Chinese Hepatology

摘　　要：目的评价自体外周血干细胞移植治疗失代偿期肝硬化的效果。方法选择42例住院治疗的失代偿期肝硬化患者,分为干细胞移植组20例和对照组22例,两组均予以相同的内科综合治疗,干细胞移植组加行经肝动脉自体外周血干细胞移植术,观察患者术后乏力、纳差、腹胀等主要症状的变化,检测移植术后4、8、12、24周肝功能、凝血功能等指标的变化,同期检测对照组的变化。结果两组患者在治疗后观察期间的主要症状乏力、纳差、腹胀均有改善。20例干细胞移植组患者手术均成功,无特殊不良反应及并发症。术后8、12、24周干细胞移植组患者肝功白蛋白均较术前明显回升(P<0.05),与对照组比较差异有统计学意义(P<0.05)。术后12周、24周细胞移植组凝血酶原活动度以及术后24周细胞移植组凝血酶原时间较术前明显改善(P<0.05),但组间比较无统计学差异。术后12周、24周Child评分较术前及对照组明显改善,差异有统计学意义(P<0.01)。结论经肝动脉自体外周血干细胞移植治疗失代偿期肝硬化是一种安全、有效的微创治疗方法,可在一定程度上改善患者的低蛋白血症及凝血功能。Objective To evaluate decompensated hepatic cirrhosis. Methods efficacy of autologous peripheral stem Forty-two patients with decompensated cell transplantation in treatment of hepatic cirrhosis were enrolled, and divided into stem cell transplantation group （n = 20） and control group （n = 22）. Both groups received the same comprehensive treatment, while cell transplantation group additionally underwent autologous peripheral blood stem cell transplantation. Clinical manifestations including hypodynamia, anorexia and abdominal distension were observed after treatment. At week 4, 8, 12, 24 after therapy, liver function and coagulation function were tested. Results Most patients had improvement in symptoms such as hypodynamia, anorexia, abdominal distension after treatment. Successful transplantations were achieved in all the 20 patients without obvious complications. Albumin （ALB） increased obviously （P 〈0.05） at week 8 , 12 and 24 after transplantation, of which improvement was better in transplantation group than that in control group. Coagulation function improved since week 12 after transplantation, while there were no significant differences between the two groups. Child-Pugh class of transplantation group improved obviously than that of control group since weekl2 （P〈0.01）. Conclusion Transplantation of autologous peripheral stem cells via hepatic artery is safe and effective in treatment of patients with decompensated cirrhosis, for which it could improve hypoproteinemia and coagulation function.

关 键 词：自体外周血干细胞 移植 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]