SDF-1/CXCR4生物轴与眼部新生血管的研究进展  

Research progress of SDF-1/CXCR4 bio-axis in neovascular eye diseases

作　　者：曾新生[1] 姚微微[1] 

机构地区：[1]桂林医学院附属医院眼科,广西桂林541001

出　　处：《华夏医学》2015年第1期167-170,共4页Acta Medicinae Sinica

基　　金：广西教育厅科学技术课题(YBZ2014284)

摘　　要：基质细胞衍生因子-1(SDF-l)属CxC型趋化性细胞因子,又称CXCL12,主要在骨髓基质细胞和骨髓内皮等细胞表达。SDF-1/CXCR4轴在介导炎症反应、造血干细胞迁移归巢、恶性肿瘤的浸润转移等方面有重要作用。近年发现SDF-1/CXCR4轴与血管内皮生长因子在血管新生方面有着密切联系,在眼部新生血管疾病中起重要作用,为眼部新生血管的治疗提供了一个新的靶点。Abstraet：Stromal cell derived factor 1 （SDF-1）, also named CXCL12, belongs to CxC chemokine family, and is mainly present on bone marrow stroma cell （BMSC） and bone marrow endothelial cells. Previous studies have confirmed that SDF-1/CXCR4 bio-axis plays an important role in the inflammatory reaction, the mobilization and homing of hematopoietic stem cell, the invasion and metastasis of malignant tumor, and so on. The present research shows that SDF-1/CXCR4 axis is also closely related to expression of vascular endothelial growth factor （VEGF） in angiogenesis, which is essential for neovascular eye diseases. Thus it provides a new target for the treatment of ocular angiogenesis.

关 键 词：基质细胞衍生因子-1 趋化因子受体-4 眼部新生血管疾病 血管内皮生长因子 

分 类 号：R774.1[医药卫生—眼科]