Early hypoactivity of hippocampal rhythms during epileptogenesis after prolonged febrile seizures in freely-moving rats  

作　　者：Bo Feng Yang-Shun Tang Bin Chen Zheng-Hao Xu Yi Wang Deng-Chang Wu Hua-Wei Zhao Shi-Hong Zhang Zhong Chen 

机构地区：[1]Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University [2]Zhejiang Chinese Medical University [3]Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine [4]Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University

出　　处：《Neuroscience Bulletin》2015年第3期297-306,共10页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (91332202, 81273506, 81273492);the Program for Zhejiang Leading Team of S&T Innovation, China (2011R50014)

摘　　要：Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures （FSs） have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relationship between FSs and epilepsy. However, little is known about how epileptogenesis develops after FSs. The present study was designed to investigate acquired seizure susceptibility and analyze local field potentials during the latent period after FSs. We found that the seizure susceptibility decreased in 35-day- old （P35） FS rats but increased in P60 FS rats. Consistently, hippocampal electroencephalogram （EEG） power in every band was decreased at P35 but increased at P60 in FS rats. Our results provide direct evidence for hypoactivity but not hyperactivity during the early phase of the latent period, displaying a broad decrease in hippocampal rhythms. These characteristic EEG changes can be a useful biomarker for the early diagnosis of epileptogenesis induced by FSs.Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures （FSs） have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relationship between FSs and epilepsy. However, little is known about how epileptogenesis develops after FSs. The present study was designed to investigate acquired seizure susceptibility and analyze local field potentials during the latent period after FSs. We found that the seizure susceptibility decreased in 35-day- old （P35） FS rats but increased in P60 FS rats. Consistently, hippocampal electroencephalogram （EEG） power in every band was decreased at P35 but increased at P60 in FS rats. Our results provide direct evidence for hypoactivity but not hyperactivity during the early phase of the latent period, displaying a broad decrease in hippocampal rhythms. These characteristic EEG changes can be a useful biomarker for the early diagnosis of epileptogenesis induced by FSs.

关 键 词：febrile seizure seizure susceptibilityepilepsy hippocampal rhythms 

分 类 号：R742.1[医药卫生—神经病学与精神病学]