Ca^(2+) signaling initiated by canonical transient receptor potential channels in dendritic development  

作　　者：Shengjie Feng Zhuohao He Hongyu Li Yizheng Wang 

机构地区：[1]Laboratory of Neural Signal Transduction,Institute of Neuroscience, Shanghai Institutes of Biological Sciences, State Key Laboratory of Neuroscience [2]The Graduate School, Chinese Academy of Sciences

出　　处：《Neuroscience Bulletin》2015年第3期351-356,共6页神经科学通报（英文版）

基　　金：supported by a grant from the National Basic Research Development Program (973 Program) of China (2011CBA00400)

摘　　要：The spatial patterns of dendritic structures diverge in different types of neurons as adaptations to their unique functions. Although different intracellular mechanisms underlying dendritic morphogenesis have been suggested, it is evident that the elevation in intracellular Ca2＋ levels plays a major role in the process. Canonical transient receptor potential （TRPC） channels, known to be non-selective Ca2＋-permeable cation channels, act as environmental detectors to sense and transduce extracellular signals into different intracellular responses, including the regulation of dendritic growth, via Ca2＋ influx. Here, we review recent advances in the understanding of Ca2＋ signaling, especially signals mediated by Ca2＋ influx via TRPC channels, and the underlying molecular events in dendritic development.The spatial patterns of dendritic structures diverge in different types of neurons as adaptations to their unique functions. Although different intracellular mechanisms underlying dendritic morphogenesis have been suggested, it is evident that the elevation in intracellular Ca2＋ levels plays a major role in the process. Canonical transient receptor potential （TRPC） channels, known to be non-selective Ca2＋-permeable cation channels, act as environmental detectors to sense and transduce extracellular signals into different intracellular responses, including the regulation of dendritic growth, via Ca2＋ influx. Here, we review recent advances in the understanding of Ca2＋ signaling, especially signals mediated by Ca2＋ influx via TRPC channels, and the underlying molecular events in dendritic development.

关 键 词：DENDRITE calcium TRPC NEUROTROPHIN 

分 类 号：Q42[生物学—神经生物学]