Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese  

作　　者：Cheng-Cheng Zhang H ong-Yan Ren Ming-LiLi Qiang Wang Wei Deng Wan-Jun Guo Wei Lei Bo Xiang Lian-Sheng Zhao Xiao-Hong Ma Yong-Gang Yao Tao Li 

机构地区：[1]The Mental Health Center, West China Hospital, Sichuan University [2]The Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University [3]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences a nd Yunnan Province, Kunming Institute of Zoology

出　　处：《Neuroscience Bulletin》2015年第3期368-370,共3页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (81130024);the National Key Technology R & D Program of the Ministry of Science and Technology of China during the 12th Five-Year Plan (2012BAI01B06)

摘　　要：Dear Editor,A few studies have focused on exploring APOE gene- related effects on cognitive functions and brain activities in healthy populations. Bondi et aL found that ε4 carriers perform significantly worse on the California Verbal Learning Test than non-carriers in non-demented old subjects （mean age, 72 years）ε11. But the results are not entirely consistent. For example, Scarmeas et aL found no effect of the E4 allele on neuropsychological performance[2] in young adults, and Jochemsen et al. found that the ε4 allele is associated with age-related cognitive decline[3]. Furthermore, protective and negative effects of the E2 allele on cognition are inconsistent[4＇ s]. APOE E2 is thought to be a protective allele for AD in the elderly population due to its role in the superior cognitive performance of ε2 carriers compared to E3 or E4 carriers[5]. However, the ε2 allele has also been found to have a negative effect on AD pathology[4].Dear Editor,A few studies have focused on exploring APOE gene- related effects on cognitive functions and brain activities in healthy populations. Bondi et aL found that ε4 carriers perform significantly worse on the California Verbal Learning Test than non-carriers in non-demented old subjects （mean age, 72 years）ε11. But the results are not entirely consistent. For example, Scarmeas et aL found no effect of the E4 allele on neuropsychological performance[2] in young adults, and Jochemsen et al. found that the ε4 allele is associated with age-related cognitive decline[3]. Furthermore, protective and negative effects of the E2 allele on cognition are inconsistent[4＇ s]. APOE E2 is thought to be a protective allele for AD in the elderly population due to its role in the superior cognitive performance of ε2 carriers compared to E3 or E4 carriers[5]. However, the ε2 allele has also been found to have a negative effect on AD pathology[4].

关 键 词：Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese GENE 

分 类 号：R394[医药卫生—医学遗传学]