白介素-22在肝损伤中JAK-STAT3通路作用的研究进展  

Interleukin-22 activates JAKSTAT3 pathway: Role in liver disease

作　　者：岑瑜[1] 郭晓云[1] 姜海行[1] 

机构地区：[1]广西医科大学第一附属医院消化内科,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2015年第14期2228-2233,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81260083~~

摘　　要：白介素-22(interleukin-22,IL-22)是IL-10家族成员之一,主要是由Th22细胞分泌的细胞因子,与特异性表达I L-22受体的组织细胞相结合,进而激活信号传导与转录激活因子3(signal transducer and activator of transcription 3,STAT3)通路发挥其生物学作用.同时,STAT3通路也是IL-22在肝损伤发生发展中主要影响作用途径.IL-22对不同类型的肝损伤疾病发挥保肝作用或加重肝损伤程度.因此,本文将IL-22激活STAT3通路作用于肝损伤疾病机制进行综述,将有利于开拓新的治疗靶点.Interleukin（IL）-22 belongs to the IL-10 family and is secreted mainly by Th22 cells. IL-22 binds to IL-22 receptors which are expressed in special tissues and cells, and activates the signal transducer and activator of transcription3（STAT3） signal pathway. IL-22 has a role in liver injury primarily through activating the STAT3 signal pathway. In different typesof liver injury, IL-22 protects the liver or aggravates liver injury. This paper will review the role of IL-22 in liver disease in terms of activating the STAT3 signal pathway.

关 键 词：白介素-22 JAK-STAT3通路 肝 

分 类 号：R575[医药卫生—消化系统]