前列腺癌组织p27和OPN表达临床意义分析  

Analysis of clinical significance of p27 and OPN in Prostate cancer tissues

作　　者：王超奇[1,2] 侯建全[1] 欧阳骏[1] 袁和兴[1] 王金花[3] 

机构地区：[1]苏州大学附属第一医院泌尿外科,江苏苏州215006 [2]内蒙古民族大学附属医院泌尿外科,内蒙古通辽028007 [3]内蒙古民族大学附属医院病理科,内蒙古通辽028007

出　　处：《中华肿瘤防治杂志》2015年第11期855-857,862,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：内蒙古自治区卫生和计划生育委员会医疗卫生科研计划(201303103)

摘　　要：目的探讨前列腺癌(prostate cancer,PCa)组织p27蛋白和骨桥蛋白(osteopontin,OPN)的表达,分析其与PCa病理因素的相关性。方法选择苏州大学附属第一医院2007-09-01-2012-02-20经手术后病理确诊的80例PCa患者,免疫组织化技术检测前列腺癌组织和相应的癌旁组织p27和OPN蛋白的表达,分析其与临床病理因素的相关性。结果 80例PCa组织中,蛋白p27阳性表达率为51.3%(41/80),癌旁组织的阳性表达率为83.8%(67/80),差异有统计学意义,P=0.046;OPN阳性表达率为65.0%(52/80),癌旁组织为31.3%(25/80),差异有统计学意义,P=0.042;p27表达与PCa分级(P=0.041)、临床分期(P=0.034)和有无转移(P=0.046)有关,OPN表达与PCa分级(P=0.035)、临床分期(P=0.034)和有无转移(P=0.025)有关;p27和OPN在PCa组织中表达呈负相关,差异有统计学意义,P<0.05。结论 PCa组织中p27表达较低,OPN表达较高,两者表达负相关。联合检测p27和OPN蛋白为PCa的防治和治疗提供一种治疗策略。ECTIVE To analyze the positive expression of osteopontin（OPN）and protain27（p27）in prostate cancer（PCa）tissue,study their correlation and roles in PCa.METHODS Select a total of 80 patients in the First Hospital Affiliated to Soochow University with histologically diagnosed prostate cancer confirmed by surgery or biopsy pathology from 1Sep.2007 to 20Feb.2012,to analyze expression of OPN and p27 in prostate cancer tissue and the corresponding para-carcinoma tissue using imunohistochemistry.RESULTS The positive expression rate of p27 was 51.3%（41/80）in prostate cancer tissue and 83.8%（67/80）in the corresponding para-carcinoma tissue,with statistical significance（P=0.046）,while the positive expression of OPN in prostate cancer tissue was 65.0%（52/80）and 31.3%（25/80）in the conrresponding para-carcinoma tissue,which also showed a statistically significant difference（P=0.042）.The different expressions of p27 were related to the tumor grade（P=0.041）,clinical stages（P=0.034）and clinical metastasis（P=0.046）.The different expressions of OPN were also related to the tumor grade（P=0.035）,clinical stages（P=0.034）and clinical metastasis（P=0.025）.There was negative correlation between the p27 and OPN in prostate cancer tissue（P〈0.01）,the difference had statistical significance.CONCLUSION The joint detection of p27 and OPN may offer an effective therapeutic strategy for the prevention and treatment of prostate cancer.

关 键 词：前列腺癌 蛋白p27 骨桥蛋白 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]