法舒地尔不同给药途径治疗介入操作中脑血管痉挛的疗效评价  

The effect evaluation for the treatment of cerebral vasospasm patients with interventional operation by fasudil different method

作　　者：卢军栋[1] 苏鹏[1] 齐凡星[1] 刘洁[1] 李肯 张会朵[1] 常文龙[1] 

机构地区：[1]保定市第一中心医院神经内科,河北保定071000

出　　处：《临床和实验医学杂志》2015年第11期914-916,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨介入操作中发生脑血管痉挛(CVS)时,法舒地尔不同给药途径治疗CVS的临床疗效,并观察其安全性及预后,为临床治疗提供依据。方法回顾性选取2009年5月至2014年5月介入操作发生CVS的患者80例资料。随机分为对照组和观察组,两组各40例。对照组:法舒地尔30 mg加入0.9%氯化钠注射液100 ml通过静脉点滴途径给药;观察组:法舒地尔15 mg加入0.9%氯化钠注射液100 ml,经微导管注入脑血管痉挛发生部位。观察两组患者的临床疗效,发挥作用时间及安全性。结果观察组患者总有效率为95.00%(38/40),高于对照组80.00%(32/40),差异具有统计学意义(P<0.05)。观察组患者平均解痉时间为11.71±3.45 min,少于对照组24.68±4.42 min,差异具有统计学意义(P<0.05)。观察组患者治疗后GCS评分和GOS评分分别为13.16±0.52和4.82±0.34,均高于对照组治疗后,差异具有统计学意义(P<0.05)。两组患者不良反应结果比较,差异无统计学意义(P>0.05)。结论脑血管疾病介入操作治疗中发生CVS,通过微导管动脉注入法舒地尔,应用剂量小,临床治疗效果更佳,起效时间短,预后良好,安全有效。Objective To explore the effect evaluation for the treatment of cerebral vasospasm（ CVS）patients with interventional opera-tion by fasudil different method,and observe its safety and prognosis,provide the basis for clinical treatment. Methods 80 CVS patients with in-tervention treatment operation were selected in the hospital from May in 2009 to May in 2014 retrospectively. They were randomly divided into the control group and the observation group,40 cases each group. The control group,fasudil 30 mg added 0. 9% sodium chloride injection 100 ml by intravenous drip. The observation group,15 mg added into 0. 9% sodium chloride injection 100 ml,the micro catheter cerebral vasospasm injection location. To observe the clinical effect of two groups,work time and the safety. Results The total effective rate of the observation group was 95. 00%（38/40）,higher than the control group 80. 00%（32/40）,the difference was statistically difference（ P 〈0. 05）. The average spasmolysis time of the observation group was 11. 71 ± 3. 45 min,shorter than that of control group 24. 68 ± 4. 42 min,difference was statistically difference（ P 〈0. 05）. GCS score and GOS scores of the observation group after treatment were 13. 16 ± 0. 52 and 4. 82 ± 0. 34,higher than the control group after treatment,the difference was statistically difference（ P 〈0. 05）. Conclusion CVS in cerebrovascular disease intervention operation can be treated through the micro catheter arterial,which can be less dosage application,better clinical curative effect,short working time,the prognosis is good,safe and effective.

关 键 词：介入治疗 脑血管痉挛 法舒地尔 给药途径 

分 类 号：R743[医药卫生—神经病学与精神病学]