氢盐水对心肺复苏后大鼠脑损伤的干预机制研究  

Intervention Mechanism of Hydrogen Saline on Brain lnjury in Rats After Cardiopulmonary Resuscitation

作　　者：江宇[1] 廖洋[1] 罗春[1] 刘刚[1] 

机构地区：[1]重庆医科大学附属大学城医院,重庆401331

出　　处：《保健医学研究与实践》2015年第3期10-12,共3页Health Medicine Research and Practice

基　　金：重庆市卫生和计划生育委员会医学科研项目(2012-2-153)

摘　　要：目的探讨氢盐水对心肺复苏(CPR)后大鼠脑损伤的干预程度及机制。方法将18只雄性清洁级SD大鼠随机分为对照组(Con组)、常规复苏组(ROSC组)和氢盐水干预组(ROSC+HRS组),每组6只,建立CPR大鼠模型,于自主循环恢复后12h行神经功能缺损评分(NDS),并测定大鼠脑组织含水量及脑组织匀浆丙二醛(MDA)含量。结果 ROSC+HRS组大鼠NDS评分明显高于ROSC组,脑组织含水量明显低于ROSC组,脑组织匀浆MDA含量明显低于ROSC组,差异均有统计学意义(P<0.05)。结论大鼠CPR后常出现神经元细胞坏死、脑水肿,利用氢盐水干预CPR大鼠可减轻大鼠CPR后的脑损伤,可能与氢盐水能减轻CPR引起的氧化应激损伤有关。Objective To investigate the level of intervention and mechanism of hydrogen saline on brain injury in rates after cardiopulmonary resuscitation（CPR）.Method 18 male Sprague-Dawley（SD）rats were randomly divided into a control group（Con group）,a resuscitation of spontaneous circulation group（ROSC group）and an intervention group of hydrogen saline（ROSC＋ HRS group）,6rats in every group,to establish CPR model and take neurological deficit scores（NDS）after 12 hours of recovery of spontaneous circulation and to measure the water content and the malondialdehyde（MDA）content of rat brain tissues.ResultsROSC＋HRS group had a significantly higher NDS and much lower water content and MDA content of brain tissues than ROSC group,the differences were statistically significance（P〈0.05）.Conclusion Rats often have neurons necrosis and cerebral edema after CPR and the intervention of hydrogen saline can reduce their brain injury in rats,probably because hydrogen saline may relieve the oxidative injury induced by CPR.

关 键 词：心肺复苏 脑损伤 氢盐水 

分 类 号：R459.7[医药卫生—急诊医学]