Quantitative measurement of the mechanical properties of human antibodies with sub-lO-nm resolution in a liquid environment  

作　　者：Agnieszka Voss 

机构地区：[1]Center of Smart Interfaces, Technische Universitot Darmstadt, Alarich-Weiss-Str 10, 64287 Darmstadt, Germany [2]Physics of Surfaces, Institute of Materials Science, Technische Universit~t Darmstadt, Alarich-Weiss-Str. 16, 64287 Darmstadt, Germany

出　　处：《Nano Research》2015年第6期1987-1996,共10页纳米研究（英文版）

摘　　要：The nanomechanical properties of single human immunoglobulin G and M antibodies were measured in a liquid environment using a fast force-volume technique with sub-10-nm spatial resolution. The ultrastructural details of these molecules were resolved in the images. Simultaneously, important physical properties, including elasticity, adhesion, and deformation were measured. The dimensions and adsorption of the immunoglobulin M antibodies onto the substrate indicated that they are highly by a low elastic stiffness （34 ± 10 MPa） flexible. The antibodies were characterized and high deformability （1.5 ± 0.5 nm）.

关 键 词：atomic force microscopy structure and physicalproperties piconewton forces FLEXIBILITY ANTIBODIES IMMUNOGLOBULIN 

分 类 号：S852.43[农业科学—基础兽医学] TP751[农业科学—兽医学]