MR扩散加权成像和分子成像在卵巢肿瘤微环境中的应用研究进展  

Research progresses of diffusion weighted and molecular MR imaging in microenvironment of ovarian tumors

作　　者：殷兵[1] 李文华[1] 

机构地区：[1]上海交通大学医学院附属新华医院放射科,上海200092

出　　处：《国际医学放射学杂志》2015年第3期242-245,共4页International Journal of Medical Radiology

摘　　要：卵巢癌是女性生殖系统的常见恶性肿瘤之一,其早期发现困难,确诊时多为中晚期,常有腹膜转移,手术难以完全切除,复发率高。这与由肿瘤细胞、肿瘤基质成分、炎性细胞和间质细胞构筑的肿瘤微环境中启动肿瘤细胞生长、开启肿瘤血管生成、促进肿瘤细胞迁徙和浸润、肿瘤细胞免疫逃逸等决定病人预后的一系列发生机制不明有很大关系。采用结构成像、功能成像和分子成像相结合的医学成像方法,进行实时动态、多元精准和在体无创研究及评估卵巢癌微环境,对监测卵巢癌的生物学行为和疗效以及预后判断具有重要意义。Ovarian cancers, as common malignant tumors in female reproductive system, are difficult to be detected in early phase and are diagnosed in mid-late stage in most cases, often accompanied with peritoneal metastasis, which results in a difficulty of complete resection and a high recurrence rate. These conditions are closely linked to the unclearuess of a series of mechanisms that trigger tumor growth, initiate tumor angiogenesis, promote tumor migration and invasion and facilitate immune evasion in the tumor microenvironment composed by tumor cells, tumor matrix, inflammatory cells and stromal cells. Studying and estimating ovarian tumor microenvironment in a dynamic, muhivariant and noninvasive way with structural, functional and molecular imaging methods together is of great importance to monitor biological behavior and therapeutic effect of ovarian tumors and to judge tumor prognosis.

关 键 词：卵巢肿瘤微环境 扩散加权成像 分子成像 细胞密度 微血管密度 肿瘤相关巨噬细胞 叶酸受体 

分 类 号：R730.51[医药卫生—肿瘤]