p75^(NTR)在乳腺癌中的表达及其临床意义  

Expression of neurotrophins receptor p75^(NTR) in breast cancer and clinical pathological features

作　　者：邓晓芳[1,2] 徐萌[1] 徐岗[3] 刘太省[3] 

机构地区：[1]暨南大学附属第一医院肿瘤科,广州市510630 [2]广州医科大学附属肿瘤医院内二科,510095 [3]广州医科大学附属肿瘤医院胸外科,510095

出　　处：《实用医学杂志》2015年第10期1594-1596,共3页The Journal of Practical Medicine

基　　金：吴阶平医学基金科研项目(编号:320675014198)

摘　　要：目的:探讨神经营养因子受体p75NTR在乳腺癌中的表达及与临床病理、激素受体、分子分型之间是否存在相关性。方法:利用免疫组织化学法检测186例乳腺癌组织p75NTR、ER、PR、HER2、Ki-67的表达情况,分析p75NTR与临床病理参数间的相关性。结果:p75NTR在乳腺癌组织中阳性表达占11.3%(21/186),p75NTR的表达与组织分级、Ki-67蛋白水平正相关(P<0.05),与ER表达负相关(P<0.05),与肿瘤大小、是否绝经、淋巴结转移等无关(P>0.05),但在淋巴结转移分层分析中淋巴结转移<4枚与淋巴结≥4之间,p75NTR的表达与之相关(P<0.05);p75NTR表达与Luminal B型及三阴乳腺癌亚型显著相关。结论 :p75NTR可预测三阴乳腺癌及Luminal B亚型,较准确地进行分子分型,为指导临床分层治疗提供依据。Objective To investigate neurotrophins receptor p75NIR expression levels in breast cancer and evaluate the correlation among pathological features. Methods Immunohistochemistry was performed to detect the expression of p75NIR, ER, PR, HER2 and Ki-67 in 186 breast cancer patients. The association among their expression levels and elincopathologic parameters were analyzed. Results The expression rate of p75NIR in breast cancer was 11.3% （21/186）.The p75NIR expression was found to be positively correlated with high tumor grade and Ki67 （P〈0.05）, but negatively with hormonal receptors. It showed no association with tumor size, menopause status and lymph node metastasis （P〉0.05）, but the difference in the p75NIR expressions in the cases with metastases in fewer than axillary lymph nodeswas statistically significant as compared to those with metastases in more than 4 nodes （P〈0.05）. Among different molecular subtypes, it was positively associated with luminal B, and triple negative breast cancer TNBC subtypes. Conclusions These findings suggest that p75NIR expression could be indicative of the TNBCs and luminal B subtypes. It may represent a potential adjunct marker for these two subtypes.

关 键 词：乳腺肿瘤 神经营养因子受体p75NTR 临床意义 

分 类 号：R737.9[医药卫生—肿瘤]