Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents  

作　　者：Rongli Cui Juan Li Huan Huang Mingyi Zhang Xihong Guo Yanan Chang Min Li Jinquan Dong Baoyun Sun Gengmei Xing 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy otScience (CAS), Beijing 700049, China

出　　处：《Nano Research》2015年第4期1259-1268,共10页纳米研究（英文版）

摘　　要：Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging （MRI） contrast agent. The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82（OH）x, in Tl-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd^3＋ ions. A ＂secondary spin-electron transfer＂ relaxation mechanism was proposed to explain how the encaged Gd^3＋ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.新奇的碳 nanohybrids 成功地用作一个新磁性的回声成像 MRI 对比代理人基于未修改的 metallofullerenes 被制作了。nanohybrids 显示出更高的 R < 潜水艇 class= “ a-plus-plus ” > 1 </sub> relaxivity 和更好的使 Gd@C 明亮效果比 < 潜水艇 class= “ a-plus-plus ” > 82 </sub > 哦 < 潜水艇 class= “ a-plus-plus ” > 在 T 的 X </sub>,< 潜水艇 class= “ a-plus-plus ” > 在 vivo 的 1 幅 </sub>-weighted 先生图象。这是从原来的 gadofullerenes 的质子 relaxivity 的结果，它保留了完美的碳笼子结构可能完全那么避免 Gd 的版本 < 啜 class= “ a-plus-plus ” >3+ 个 </sup> 离子。第二等的纺纱电子转移松驰机制被建议解释怎么 encaged Gd < 啜 class= “ a-plus-plus ” > 碳 nanohybrids 的 3+ 个 </sup> 离子与包围的水分子交往。这条途径为开发高度有效、低的毒性 MRI 对比代理人打开新机会。

关 键 词：graphene oxide METALLOFULLERENE magnetic resonanceimaging （MRI） NANOHYBRIDS 

分 类 号：O641.4[理学—物理化学] TQ463[理学—化学]