男性抑郁症患者静息态脑区局部一致性特征及其病情程度的相关性  

Relationship between regional homogeneity of male depressed patients and the severity of depression： a resting-state fMRI study

作　　者：韦秋香 姚志剑[1,2] 阎锐[2] 韦茂彬[3] 花玲玲[1] 卢青[3,4] 

机构地区：[1]南京大学医学院,南京210093 [2]南京医科大学附属脑科医院抑郁症专科 [3]东南大学学习科学研究中心 [4]东南大学苏州研究院

出　　处：《中华行为医学与脑科学杂志》2015年第5期435-437,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81371522,61372032）;江苏省医学专项（BL2012052,BL2014009）;江苏省自然科学基金项目（BK2012740,BK20131074）;国家临床重点专科（卫生部医政司 2011-873）;江苏省医学重点学科（江苏省科教处 2011-12）

摘　　要：目的 探讨中青年男性抑郁患者静息态下局部脑区神经活动的一致性ReHo（regional homogeneity）特征,及异常脑区的ReHo值与病情严重程度的相关性.方法 19例男性抑郁患者与19例受教育年限匹配的男性健康对照进行3.0T静息态功能磁共振扫描.计算全脑ReHo值并进行统计分析,经Al-phasim矫正后,将异常脑区的ReHo值与汉密尔顿抑郁量表总分进行相关分析.结果 男抑郁患者组较对照组双侧海马旁回（-30,-42,-9;K=43;27,-33,-12;K=18）、右前扣带回（3,15,33;K=54）ReHo值增高,右中央后回（27,-36,54;K=21）ReHo值降低（P＜ 0.05,Alphasim矫正）.相关分析显示,右海马旁回ReHo值与患者HAMD-17总分呈正相关（r=0.535,P=0.018）.结论 男性抑郁患者在静息状态下存在边缘系统相关脑区的异常,其损害程度与患者疾病严重程度相关.Objective To explore the regional homogeneity （ReHo） feature of the spontaneous neural activity within young male depressed patients,and conduct correlation analysis of the abnormal regions with the severity of depressive symptoms.Methods 19 male depressed patients and 19 educated age-matched male healthy controls were undergone resting-state functional magnetic resonance imaging scanning at 3.0 Tesla.The whole brain＇ s regional homogeneity was calculated.The ReHo values of abnormal brain regions after alphasim correction were conducted correlation analysis with the total score of Hamilton Rating Scale for Depression.Results As compared with the controls,the depressed patients exhibited significantly increased ReHo in the bilateral parahippocampal （-30,-42,-9：K=43：27,-33,-12：K=18） and the right posterior cingulate gyrus（3,15,33：K=54）,while decreased ReHo in the right postcentral gyms （27,-36,54,K =21） （P＜0.05,Alphasim）.The correlation analysis showed that the ReHo of the right parahippocampal gyrus was positively correlated with the HAMD17 total scores （r=0.535,P=0.018）.Conclusions The male depressed patients exhibit abnormities in the limbicrelated brain regions during rest,and the extent of damage is correlated with the severity of depression.

关 键 词：抑郁症 性别 静息态 局部一致性 病情 

分 类 号：R749.4[医药卫生—神经病学与精神病学]