38例恶性黑色素瘤临床及病理分析  

Clinical and pathological analysis of 38 malignant melanoma cases

作　　者：张萍[1] 杨海军[1] 苗兰芳[1] 孟宪宇[1] 

机构地区：[1]河南安阳市肿瘤医院病理中心,455000

出　　处：《中国实用医药》2015年第13期31-32,共2页China Practical Medicine

摘　　要：目的探讨恶性黑色素瘤(MM)的临床及病理特征,提高其早期的诊断率。方法回顾性分析38例恶性黑色素瘤患者的临床资料及病理特征。结果 38例患者均为中老年人,肿瘤发生于全身多处部位,以四肢皮肤多见;免疫组化结果及阳性率显示:vimentin、Melan-A、S-100、HMB45阳性率分别为100.0%(28/28)、95.0%(19/20)、89.5%(17/19)、85.0%(17/20),AE1/AE3全部为阴性,ki-67全部为阳性。结论恶性黑色素瘤是一种少见的高度恶性肿瘤,发病较隐匿,发病部位较广泛,病理组织结构复杂多样,极易误诊;免疫组化抗体中HMB45、Melan-A、S-100具有重要诊断意义,vimentin、AE1/AE3、LCA、ki-67具有重要鉴别诊断价值。Objective To investigate the clinical and pathological characteristics of malignant melanoma （MM）, and to improve its early diagnosis rate.Methods Clinical analysis and pathological characteristics of 38 malignant melanoma patients were retrospectively analyzed.Results All the 38 cases were senile patients, and their tumor located in various positions, mainly on limb skin. Immunohistochemical results and positive rates showed that the positive rates of vimentin, melan-A, S-100, HMB45 were respectively 100.0% （28/28）, 95.0% （19/20）, 89.5% （17/19）, 85.0% （17/20）, AE1/AE3 were all negative, and ki-67 were all positive. Conclusion Malignant melanoma is an rare highly severe tumor with hidden and wide morbidity. Due to its complicated and various histopathological structures, it is easily misdiagnosed. Immunohistochemical antibodies HMB45, melan-A and S-100 contains important diagnosis significance, and vimentin, AE1/AE3, LCA, and ki-67 have remarkable value in distinguish and diagnosis.

关 键 词：恶性黑色素瘤 临床 免疫组化 病理组织学特点 

分 类 号：R739.5[医药卫生—肿瘤]