直肠癌组织podoplanin的表达与淋巴结转移关系的研究  

Relationship of podoplanin expression of rectal cancer and lymphatic metastasis

作　　者：卿佳林 田小林[2] 朱小宝[2] 

机构地区：[1]桂林医学院,广西桂林541004 [2]桂林医学院附属医院胃肠外科,广西桂林541001

出　　处：《华夏医学》2015年第2期26-29,共4页Acta Medicinae Sinica

摘　　要：目的:观察podoplanin在直肠癌组织淋巴管内皮细胞上的表达情况,为研究淋巴结转移提供病理形态学依据。方法:用SP免疫组化法检测实验组和对照组podoplanin的表达情况。结果:实验组的LMVD高于对照组的LMVD(P<0.05);同时A组中淋巴结转移组高于淋巴结未转移组,差异有统计学意义(P<0.05)。结论:podoplanin特异表达于淋巴管内皮细胞上,可区别微淋巴管与微血管,在直肠癌组织、癌旁组织中高表达,推测直肠癌的淋巴结转移可能与淋巴管数量的增加相关。Objective： To observe the expression of podoplanin in the lymphatic endothelial cells of rectal tissues for providing pathomorphism basis for the research of lymphatic metastasis. Methods： SP immunohistochemical （IHC） method was used to detect the podoplanin expressions in the experimental group and the control group. Results. LMVD of the experimental group was higher than that of the control group （P〈0.05） ; At the same time, LMVD of the lymphatic metastasis group was higher than that of the non-lymphatic metastasis group, which was of statistical differ ence （P〈0.05）. Conclusion： Podoplanin specifically expresses in the lymphatic endothelial cells, which can distinguish microlymphatic vessels from capillaries. The high expression of podoplanin in rectal tissues and tissues adjacent to cancer may suggest that the lymphatic metastasis rectal cancer may be related to the increase of the number of lymphatic vessels.

关 键 词：直肠肿瘤 PODOPLANIN 淋巴管 微淋巴管 

分 类 号：R735.37[医药卫生—肿瘤]