树突状细胞亚群与肿瘤免疫治疗  

Dendritic Cell Subsets and Tumor Immunotherapy

作　　者：田丰 周凯[2] 王龙信[2] 

机构地区：[1]解放军第二О一医院泌尿外科,辽宁大连116023 [2]南京军区南京总医院泌尿外科,南京210002

出　　处：《医学综述》2015年第11期1967-1969,共3页Medical Recapitulate

基　　金：国家自然科学基金(81472392;81372741)

摘　　要：树突状细胞(DC)在诱导和调节免疫反应中起关键作用,包括激活消除肿瘤细胞的细胞毒性T淋巴细胞。以DC为基础的肿瘤疫苗能够被机体耐受、很少有不良反应,同时又能诱导抗肿瘤的免疫反应,但是其效果有限。研究表明,DC具有多种表型,CD141+DC在抗肿瘤反应中扮演着重要的角色。这成为DC疫苗在体内应用发展的新方向。对不同DC亚群特殊功能的深入了解,以及对肿瘤抗原负载新方法的研究,为设计出更有效的DC肿瘤疫苗指出了一条更有希望的道路。Dendritic cells（DC） play a key role in the induction and regulation of immune responses, including the activation of cytotoxic T lymphocytes for the eradication of cancers .DC-based cancer vaccines can be tolerated,with few side effects and can induce anti-tumor immune responses,but the overall effects are limited.Recent studies showed that CD141 ＋DC play an important role in anti-tumor responses.These are now novel targets for the development of vaccines that directly target DC in vivo .With the deepening of the under-standing of the specialized functions of DC subsets,strategies for the delivery of tumor Ag to DC,a promising new direction for the design of more effective DC-based cancer vaccines is pointed out.

关 键 词：树突状细胞 亚群 疫苗 肿瘤 免疫治疗 

分 类 号：R730.5[医药卫生—肿瘤]