细胞穿膜肽介导蛋白/多肽类药物输送的研究进展  

Recent Developments in Cell-penetrating Peptidemediated Protein/Peptide Drug Delivery

作　　者：张娅洁 陈应之 杨志民[2,3] 黄永焯[1] 

机构地区：[1]中国科学院上海药物研究所,上海201203 [2]天津医科大学药学院天津市临床药物关键技术重点实验室,天津300070 [3]美国密西根大学药学院,密西根州安娜堡48109

出　　处：《药学进展》2015年第4期270-276,共7页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.81373357;81422048;81172996;81361140344)

摘　　要：在当前药物研发中,蛋白/多肽类药物占据着重要地位。然而,此类药物大多需进入细胞内才能发挥作用,故细胞摄取率低的问题成为制约其发展的关键因素。细胞穿膜肽是一类富含精氨酸的短肽,自身具有较强的生物膜穿透能力,可携带多种大分子甚至是纳米粒入胞。因此,穿膜肽被广泛应用于药物输送,且基于穿膜肽介导药物胞内输送,成为解决蛋白/多肽类药物入胞问题的优选策略。主要综述穿膜肽介导蛋白/多肽类药物输送用于不同疾病治疗的研究进展。Protein/peptide drugs have received great attention and recognition, and taken a growing share in drug development. However, intracellular delivery has become an essential issue tbr many protein/peptide drugs that need to enter the cells for achieving pharmacological actions. Cell-penetrating peptides （CPPs） are rich in arginine, which enables them not only to penetrate cell membrane efficiently, but also to carry a variety of macromolecules into cells. Therefore, CPPs have been widely applied in drug delivery, and especially, CPP-based technique is considered as the promising solution to overcome the barriers against effective intracellular protein delivery. This article provided emphatically an overview on recent development in CPP-mediated protein/peptide drug delivery for treatment of various diseases.

关 键 词：细胞穿膜肽 蛋白 多肽 胞内输送 

分 类 号：R943[医药卫生—药剂学]