联合检测F-PSA、T-PSA及F-PSA/T-PSA比值在前列腺疾病诊断中的意义  

The Value of Combined Detection of F-PSA,T-PSA and F-PSA / T-PSA in the Diagnosis of Prostatic Diseases

作　　者：赵乔妹[1] 时宇[1] 张静[1] 王海滨[1] 

机构地区：[1]解放军总医院第一附属医院检验科,北京100048

出　　处：《标记免疫分析与临床》2015年第6期487-489,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的 探讨血清游离前列腺特异性抗原（F-PSA）、总前列腺特异性抗原（T-PSA）和F-PSA/T-PSA比值在前列腺疾病诊断中的意义.方法 选取2012年10月至2014年10月我院泌尿外科的前列腺疾病患者190例.通过化学发光法测定其血清中F-PSA、T-PSA的含量,计算F-PSA/T-PSA比值,并与100例健康体检者进行比较.结果 前列腺增生（BPH）组和前列腺癌（PCa）组F-PSA、T-PSA均显著高于正常对照组（P＜0.01）; PCa患者组与BPH患者组差异亦存在统计学意义（P＜0.01）.当T-PSA在4～ 10 ng/mL之间时,BPH患者组和PCa患者组T-PSA水平差异无统计学意义（P＞0.05）;但PCa患者组F-PSA/T-PSA明显低于BPH患者组,差异具有统计学意义（P＜0.01）.结论 同时检测F-PSA、T-PSA并计算F-PSA/T-PSA比值明显优于单纯检测T-PSA,在前列腺疾病的鉴别诊断中具有重要的意义.Objective To study the value of serum free prostate specific antigen （F-PSA）, total prostate specific antigen（T-PSA） and （F-PSA）/（T-PSA） ratio in the diagnosis of prostatic disease. Methods 190 patients of prostatic diseases from urology surgery in our hospital from Oct 2012 to Oct 2014 were selected in the study. F- PSA and T-PSA were determined by CMIA in 190 patients and 100 controls, and the ratio of F-PSA to T-PSA was calculated. Results Serum F- PSA, PSA in benign prostatic hyperplasia （BPH） group and prostate cancer （PCa） group were significantly higher than that in normal group （ P 〈 0.01 ）, while had significant difference between BPH group and PCa group （P 〈 0.01 ）. When it was between 4-10ng/ml, T-PSA in BPH had no significant difference with that in PCa group （ P 〉 0.05 ）. The ratio of F-PSA to T-PSA in PCa group was significantly lower than that in BPH group （P 〈 0.01 ）. Conclusion The value of combined detection of F-PSA, T-PSA and F-PSA/T-PSA could be significantly better than determining PSA alone in the diagnosis of prostatic disease.

关 键 词：前列腺癌 良性前列腺增生 F—PSA T—PSA 诊断 

分 类 号：R737.25[医药卫生—肿瘤]