饮酒和HBsAg与肝细胞肝癌的关联性研究  

Study on relationship between alcohol drinking,HBsAg and HCC

作　　者：李辉[1] 刘诗义[1] 刘健[1] 曹广劭[1] 王玉丹[1] 刘玉岩[1] 曹会存[1] 

机构地区：[1]郑州大学河南省人民医院介入科,郑州450003

出　　处：《医药论坛杂志》2015年第5期12-14,共3页Journal of Medical Forum

基　　金：河南省科技厅科技攻关项目(112102310227)

摘　　要：目的描述肝细胞肝癌(HCC)患者的流行病学特点,了解HCC与年龄、饮食习惯、行为习惯以及生活习惯的关系,阐明饮酒与HCC发生的危险性。方法采用病例-对照研究方法,采用问卷调查表的形式调查HCC患者200例,将其各项资料录入电脑,采用多元回归方法估计比值比(OR)及95%可信区间(95%CI)。结果对两组患者基本特征进行单因素分析,发现与肝癌发生密切相关的因素有:HBsAg阳性、肝硬化、慢性肝病以及血吸虫病,饮酒与肝癌之间未发现显著性相关,且在进一步分析中,饮酒年数、乙醇摄入量以及饮酒年龄等因素之间,亦未发现有明确相关性。但HBsAg阳性、存在慢性肝病病史与肝癌的发生密切相关,HBs Ag阳性患者的肝癌发生率明显升高,但在阴性研究对象中,是否饮酒对肝癌的发生无明显相关性,不具有统计学意义(P>0.05);在慢性肝病阳性的研究对象中,饮酒者肝癌发生的可能性较不饮酒者明显升高,并且此种情况随着饮酒量的增加,此危险性有放大趋势。结论 HBsAg阳性和慢性肝病为肝细胞肝癌的独立危险因素,饮酒虽然并非其危险因素之一,但在HBsAg阳性以及具有慢性肝病病史人群中,饮酒行为将放大HCC发生的可能性,并且这种情况可能随着酒精的摄入量的增加而变得更加明显。Objective To describe the epidemiological characteristics of HCC patients; to get a good knowledge about the relationship between age, dietary habit, behavioral habit, living habit and HCC, to illustrate the risk of causing HCC by alcohol drinking. Methods The case - control study was used. In the form of questionnaire, 200 HCC patients were investigated, and their related information was stored in computer. Meanwhile the odds ratio （OR） and 95% Confidence interval （95% CI） were estimated by using multiple regression method. Results Through single factor analysis of the basic characteristics of the two groups of patients, the factors closely related with liver cancer were discovered and they were HBsAg positive,liver cirrhosis, chronic liver disease and schistosomiasis. And it also discovered that there was no obvious correlation between drinking and liver cancer. In addition, in further analysis, any clear correlation between the number of drinking years, alcohol intake, and drinking age was not found. Depending on whether HBsAg was positive and whether there was a history of chronic liver disease, through analyzing the correlation between alcohol consumption and liver cancer, it turned out that there was still a close relationship between HBsAg positive, having a history of chron- ic liver disease and causing liver cancer. The ratio of causing liver cancer in patients with HBsAg positive was obvious higher, while in the study of patients with HBsAg negative, there was no clear relationship between drinking and liver cancer, and it was statistically non -significant. In the study of patients with chronic liver disease positive, the risk of causing liver cancer among drinking patients was higher than that among non - drinking patients. Besides, in this case, the risk would be higher with the alcohol consumption increasing. Conclusion HBsAg positive and chronic liver dis- ease are independent risk factors for hepatocellular carcinoma. Though drinking is not an independent risk factor, it finds that drinkin

关 键 词：酒精 HBSAG 肝细胞肝癌 危险因素 

分 类 号：R735.7[医药卫生—肿瘤]