RGC-32和ZEB1在胃癌组织中的表达  

Expressions of RGC-32 and ZEB1 in the Gastric Carcinoma

作　　者：夏祥伟[1] 茅国新[1] 

机构地区：[1]高邮市人民医院,江苏扬州225600

出　　处：《肿瘤基础与临床》2015年第3期193-197,共5页journal of basic and clinical oncology

摘　　要：目的探讨补体反应基因-32(RGC-32)与锌指E盒结合蛋白(ZEB1)在胃癌组织中的表达及意义。方法应用免疫组化S-P法分别检测60例胃癌、,60例癌前病变、20例正常胃黏膜组织中RGC-32和ZEB1蛋白的表达情况。结果 RGC-32在胃癌、癌前病变及正常胃黏膜组织中的阳性表达率依次降低,分别为78.3%、41.7%、40.0%(P<0.05)。ZEB1在胃癌、癌前病变及正常胃黏膜组织中的阳性表达率亦依次降低,分别为88.3%、50.0%、20.0%(P<0.05)。胃癌组织中RGC-32和ZEB1的表达与胃癌的病理分化程度、TNM分期和淋巴结转移有关(P<0.05)。胃癌组织、癌前病变组织中的RGC-32与ZEB1表达均呈正相关关系(r=0.568、0.452,P<0.05)。结论 RGC-32、ZEB1的异常表达可能促进胃癌的发生、发展和浸润转移,两者可能作为胃癌诊断和预后判断的指标,有可能成为胃癌治疗的新靶点。Objective To investigate the expressions and significance of response gene to complement-32 （ RGC- 32） and zinc-finger E-box-binding homeobox factor 1 （ZEB1） in the gastric carcinoma. Methods Immunohisto- chemistry S-P method was used to detect the RGC-32 and ZEB1 expressions in the 60 specimens of gastric carcino- ma,60 specimens of precancerous lesion and 20 specimens of normal gastric mucosa. Results The expression rate of RGC-32 in the gastric carcinoma, precancerous lesion, and normal gastric mucosa were 78.3% ,41.7% and 40.0% ,respectively （P 〈 0.05 ）. The expression rate of ZEB1 in the gastric carcinoma, precancerous lesion, and normal gastric mucosa were 88.3% ,50.0% and 20.0%, respectively （P 〈 0.05 ）. In the gastric carcinoma, the RGC- 32 and ZEB1 expressions were related to differentiated degree ,TNM stage and lymph-node metastasis （P 〈 0.05）. Positive correlation was build up between the RGC-32 and ZEB1 expressions in the gastric carcinoma （r = 0.568 ,P 〈 0.05 ） and precancerous lesion （r = 0. 452 ,P 〈 0.05 ）. Conclusion RGC-32 and ZEB1 may promote the development,infiltration and metastasis of gastric carcinoma, RGC-32 and ZEB1 are possible molecular markers of gastric carcinoma, may be used in the diagnosis and prognosis, and can be as the therapeutic targets of gastric carcinoma.

关 键 词：补体反应基因-32 锌指E盒结合蛋白 胃癌 

分 类 号：R735.2[医药卫生—肿瘤] R730.23[医药卫生—临床医学]