中等剂量卡培他滨单药治疗老年转移性乳腺癌的临床观察  

Moderate-dose Capecitabine Monotherapy in the Treatment of Elderly Patients with Metastatic Breast Cancer

作　　者：庞慧[1] 杨晓[1] 聂芳芳[1] 

机构地区：[1]焦作市第二人民医院肿瘤内科,河南焦作454001

出　　处：《肿瘤基础与临床》2015年第3期205-206,共2页journal of basic and clinical oncology

摘　　要：目的观察中等剂量卡培他滨单药治疗老年转移性乳腺癌的疗效和毒副反应。方法单药卡培他滨治疗39例老年转移性乳腺癌患者,每天2 000 mg·m-2,分2次口服,连用14 d,休息7 d,每21 d为1周期,直到疾病进展,最多行6周期治疗。结果全组39例老年转移性乳腺癌患者中,PR 9例,SD 25例,PD 5例,总有效率23.1%,肿瘤控制率87.2%,中位肿瘤进展时间7.6个月。毒副反应有:Ⅰ、Ⅱ度手足综合征14例(35.9%),Ⅰ、Ⅱ度骨髓抑制9例(23.1%),Ⅰ度腹泻2例(5.1%),Ⅰ度消化道反应1例(2.6%)。结论中等剂量卡培他滨单药治疗老年转移性乳腺癌安全有效,值得临床广泛推广。Objective To observe the effect and toxicities of moderate-dose capecitabine monotherapy in the treatment of elderly patients with metastatic breast cancer. Methods Thirty-nine elderly patients with metastatic breast cancer were given with capecitabine：2000 mg· m-2,2 times a day, for 14 days, then rest 7 days,was repeated every 21 days, until disease progression, up to 6 cycles. Results PR was observed in the 9 patients, SD in the 25 patients, PD in the 5 patients, the total effective rate was 23. 1%, the tumor control rate was 87.2%, the median time to tumor progression was 7.6 months. The toxicities were：14 patients （35.9%） of I and II degree hand-foot syndrome,9 patients （23.1%） of I and II degree bone marrow suppression,2 patients （5.1%） of I degree diarrhea,only one patients （2.6%） of I degree digestive tract reaction. Conclusion Moderate-dose capecitabine monotherapy is effective and safe in the treatment of elderly patients with metastatic breast cancer, which is worth clinical promotion widely.

关 键 词：中等剂量 卡培他滨 转移性乳腺癌 老年患者 

分 类 号：R737.9[医药卫生—肿瘤] R730.53[医药卫生—临床医学]