神经炎症在帕金森病中的作用及研究进展  

The Function of Neuroinflammation in Parkinson Disease

作　　者：黎俊宇 马珊珊[1] 黄巧莹 黎明涛[1] 

机构地区：[1]中山大学中山医学院药理学教研室,广州510080

出　　处：《生理科学进展》2015年第3期175-179,共5页Progress in Physiological Sciences

基　　金：国家重点基础研究发展973计划(2011CB504105)资助课题

摘　　要：帕金森病(Parkinson disease,PD)是全球第二大神经退行性疾病,病理本质是"黑质多巴胺能神经元选择性、进行性死亡",发病机制不清。研究发现神经炎症在PD病程中发挥重要作用,表现在:PD病人和动物模型中,黑质局部小胶质细胞、星形胶质细胞激活,血脑屏障受损及外周T淋巴细胞浸润。但PD中神经炎症发生的机制尚未阐明。本文将综述神经炎症在PD中的表现及发生机制的研究进展,从神经炎症的角度为PD防治的研究提供可能的思路。Parkinson disease（ PD） is the second most common neurodegenerative disorder,characterized by a progressive loss of dopaminergic neurons in the substantia nigra（ SN）. The pathology of PD remains unclear. Recent findings suggests neuroinflammation plays a critical role in PD. Occurrence of neuroinflammation,including microglia and astrocyte activation,T lymphocyte infiltration and blood-brain barrier disruption,has been identified in PD. However,the mechanism of neuroinflammation regulation in PD is not fully deciphered. In this review,we focus on the cutting edge in researches of neuroinflammation in PD,which may provide us new ideas in prevention and recovery of PD.

关 键 词：帕金森病 神经炎症 胶质细胞 抗炎治疗 

分 类 号：R364[医药卫生—病理学] R742[医药卫生—基础医学]