糖类抗原125、细胞角蛋白19片段、癌胚抗原在非小细胞肺癌中的临床应用价值  

Explore clinical diagnosis value of CA125,CYFRA21-1 and CEA in non-small cell lung cancer

作　　者：姚亚超[1] 李磊[2] 严芳[1] 邱厚匡[1] 吴晓昀[1] 李亚红[1] 李泽泳[1] 张珍[1] 李楠[1] 张智[1] 

机构地区：[1]广东省第二人民医院检验医学部,广州510317 [2]广州医科大学附属第三医院生殖医学中心/广东省生殖医学重点实验室,广州510150

出　　处：《检验医学与临床》2015年第12期1659-1660,1664,共3页Laboratory Medicine and Clinic

基　　金：国家自然科学基金项目(81400639);广州医科大学博士启动基金项目(2014C39)

摘　　要：目的探讨血清标志物糖类抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)在非小细胞肺癌(NSCLC)诊断中的临床价值。方法选择该院NSCLC患者130例、肺部良性疾病者80例,以及同期健康体检者90例(健康对照组),检测血清CA125、CYFRA21-1、CEA水平,采用Graph Pad Prism 5绘制ROC曲线,分析单独及联合检测时的诊断效能。结果 CA125、CYFRA21-1、CEA诊断NSCLC的ROC曲线下面积分别为0.836 8、0.842 4、0.785 2。CEA的灵敏度最高,CYFRA21-1的特异度最高;CYFRA21-1和CEA联合检测的准确度高于CA125和CEA。结论 CYFRA21-1和CEA联合检测不仅可用于NSCLC的诊断,还可用于特定病理类型NSCLC的鉴别诊断。Objective To evaluate the values of CA125,CYFRA21-1and CEA in diagnosing of non-small cell lung cancer（NSCLC）.Methods Serum samples from 130 NSCLC patients,80 Patients with benign lung disease and90 healthy donors were collected to detect the level of CA125,CYFRA21-1and CEA.ROC was generated by GraphPad Prism 5.We also analyze the diagnosis efficiency of the separate and combined detection.Results ROC area under curve of CA125,CYFRA21-1and CEA was 0.836 8,0.842 4and 0.785 2,separately.The sensitivity of CEA and the specificity of CYFRA21-1was the highest in the three serum biomarkers.The accuracy of the combined detection for CYFRA21-1and CEA was higher than that of the combined detection for CA125 and CEA.Conclusion Combined determination of CYFRA21-1and CEA which is superior to combined detection of CA125 and CEA,not only had significant values for the diagnosis of NSCLC,but also can identify the pathological type of NSCLC.

关 键 词：非小细胞肺癌 诊断 糖类抗原125 细胞角蛋白19片段 癌胚抗原 

分 类 号：R734.204[医药卫生—肿瘤]