丁苯酞注射液联合阿托伐他汀强化治疗急性脑梗死的临床研究  

Clinical analysis about butylphthalide and sodium chloride injection combined with atorvastatin on acute cerebral infarction

作　　者：栾松[1] 黄晓勇[1] 刘娟[1] 李浩东[1] 范永新[1] 刘猛[1] 朱月敏[1] 

机构地区：[1]北京301总医院合作医院涿州市医院,河北保定072750

出　　处：《检验医学与临床》2015年第12期1670-1671,1675,共3页Laboratory Medicine and Clinic

基　　金：河北省科技支撑计划项目(20130687)

摘　　要：目的探讨丁苯酞注射液治疗急性脑梗死的临床疗效及其安全性。方法将该院84例急性脑梗死患者分为对照组和治疗组,各42例,疗程14d。所有患者均给予拜阿司匹林100mg/d、阿托伐他汀钙80mg/d口服,银杏达莫20mL/d静脉点滴。治疗组再给予丁苯酞注射液50mg/d静脉点滴。对2组患者治疗前和治疗第14天进行美国国立卫生研究院卒中量表(NIHSS)、日常生活活动能力量表(Barthel)评分及安全性评价。结果治疗组患者治疗14d后采用NIHSS评分、Barthel评分,与治疗前比较明显改善(7.6,10.8;65.71,50.14),差异有统计学意义(P<0.05)。治疗组患者总有效率(29.63%)与对照组(58.26%)比较,差异有统计学意义(P<0.05)。治疗组患者出现1例丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)轻度升高,随访观察1个月后恢复正常。不良反应发生率低(0.25%)。结论丁苯酞注射液治疗对急性前循环脑梗死有较好的临床作用,尽早使用临床价值更大。Objective To evaluate the efficacy and safety of butylphthalide and sodium chloride injection in acute cerebral infarction.Methods 84 cases of acute cerebral infarction were diveded into teo groups.The efficacy and safety of patients were compared in therapy group（n=42）and control group（n=42）of period of treatment for 14 days.All patients were given oral drugs（Aspirin1 100mg/day,atorvastatin 80mg/day）and Ginkgo leaf extract and Dipyridamole injection（20 ml/day）.Therapy group also were given butylphthalide and sodium chloride injection.NIHSS、Barthel scale and safe indexes in two groups were analyzed.Results Two groups were no statistic difference with patient feature,disease history and first scales.The total clinical efficacy scale in therapy and control were 7.6and 10.8,65.71 and 50.14.There were statistic difference in two groups（P〈0.05）.Total efficacy were obvious statistic difference（29.63%,58.26%,P〈0.05）.Transaminase had mild high in 1case with normal recovery after one follow-up month.Adverse reactions was low（2.5%）.Conclusion The therapy with butylphthalide and sodium chloride injection was effective and safe to acute cerebral infarction.

关 键 词：丁苯酞注射液 脑梗死 美国国立卫生研究院卒中量表评分 日常生活活动能力量表评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]