脂蛋白磷脂酶A2在动脉粥样硬化性脑梗死中的临床价值  

Clinical value of lipoprotein associated phospholipase A2 in atherosclerotic cerebral infarction

作　　者：卢卫国[1] 朱晔[1] 梁志伟[1] 

机构地区：[1]广州中医药大学第一附属医院检验科,510405

出　　处：《检验医学与临床》2015年第12期1733-1734,1737,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨血浆脂蛋白相关磷脂酶A2(Lp-PLA2)与动脉粥样硬化性脑梗死(ACI)的相关性。方法按照颈动脉彩色多普勒超声检查结果,将131例ACI患者分为稳定型斑块组和不稳定型斑块组,同时设立健康对照组,采用双抗体夹心酶联免疫吸附法(ELISA)检测并比较各组血浆Lp-PLA2水平,通过绘制受试者工作特征(ROC)曲线评估其对颈动脉斑块稳定性的预测价值。结果不稳定型斑块组[(358.6±247.7)ng/mL]的血浆LpPLA2水平明显高于稳定型斑块组[(169.1±45.6)ng/mL],差异有统计学意义(P<0.01);2个病例组的血浆LpPLA2水平明显高于健康对照组[(45.5±21.2)ng/mL],差异有统计学意义(P<0.01)。2个病例组ROC曲线下面积为0.852,评估颈动脉斑块稳定性的理想临界值为187.6ng/mL,敏感度为82.6%,特异度为77.5%。结论血浆Lp-PLA2水平与ACI具有良好的相关性,能较好地评估颈动脉斑块的稳定性。Objective To study the relationship on lipoprotein associated phosphor lipase A2（Lp-PLA2）and atherosclerotic cerebral infarction（ACI）Methods According to the results of carotid artery color Doppler ultrasonography,131 cases of ACI were divided into stable plaque group and unstable plaque group,and the health were as normal control group.The Lp-PLA2 was detected by using ELISA.The value of to predict the stability of carotid plaque were assessed by drawing the ROC curveResults Lp-PLA2 in unstable plaque group[（358.6±247.7）ng/mL]was significantly higher than that in stable plaque group[（169.1±45.6）ng/mL]（P〈0.01）,the level of LpPLA2 in atherosclerotic cerebral infarction was significantly higher than those in control group[（45.5±21.2）ng/mL]（P〈0.01）.The area under the ROC curve was 0.852,the optimal cut-off point of stability evaluation of carotid plaque was 187.6ng/mL,the sensitivity was 82.6%,specificity was 77.5%.Conclusion There is a good correlation between Lp-PLA2 and atherosclerotic cerebral infarction,Lp-PLA2 can effectively assess the stability of carotid plaque

关 键 词：脂蛋白相关磷脂酶A2 动脉粥样硬化性脑梗死 斑块稳定性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]