吉非替尼治疗老年NSCLC并脑转移的疗效及可行性分析  

Curative effect and feasibility analysis of Gefitinib in treatment of senile patient with NSCLC complicated with brain metastases

作　　者：余宗阳[1] 李捷[1] 王晗[1] 阴丽慧 赵忠全[1] 

机构地区：[1]南京军区福州总医院肿瘤科,福州350025

出　　处：《西南国防医药》2015年第6期589-592,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨吉非替尼治疗老年非小细胞肺癌(NSCLC)合并脑转移的疗效及可行性。方法以吉非替尼治疗的老年NSCLC合并脑转移患者68例为观察组,给予吉非替尼250 mg/d口服;接受化疗的老年NSCLC合并脑转移患者36例为对照组,给予VIP化疗方案。对比两组治疗效果、生活质量及药物不良反应。结果观察组治疗有效率(47.1%)显著高于对照组(22.2%),临床获益率(79.4%)亦显著高于对照组(44.4%)(均P<0.05)。治疗后,观察组整体生活质量、躯体功能、社会功能得分较对照组显著升高(P<0.05);各项症状评分除恶心、呕吐外,观察组均显著低于对照组(P<0.05)。结论吉非替尼对老年NSCLC合并脑转移有一定的疗效,可改善患者的生活质量,并且安全可行,适合临床应用。To explore the curative effect and feasibility of Gefitnib in treatment of the senile patients with non-small cell lung cancer （NSCLC） complicated with brain metastases. Total 68 senile patients with NSCLC complicated with brain metastases to receive treatment with Gefitnib were selected to constitute the observation group and were treated with Gefitnib （taken orally, 250 mg per day）; another total 36 patients with NSCLC complicated with brain metastases to receive chemotherapy were selected to constitute the control group and were treated with VIP chemotherapy. And then, the curative effects, life qualities and drug adverse reactions were compared between two groups. The treatment efficiency in the observation group （47.1%） was significantly higher than that in the control group （22.2%）, and the clinical benefit rate in the observation group （79.4%） was also significantly higher than that in the control group （44.4%） （all ＆lt; 0.05）. After the treatment, the scores of the overall life quality, somatic function and social function in the observation group were significantly higher than those in the control group （ ＆lt; 0.05）; all symptom scores （except nausea and vomiting） in the observation were significantly lower than those in the control group （ ＆lt; 0.05）. Gefitnib has a certain curative effect in treatment of the senile patients with NSCLC complicated with brain metastases and can improve the life quality of the patients, and also it is safe and feasible, so it is suitable for clinical application.

关 键 词：非小细胞肺癌 脑转移 吉非替尼 生活质量 疗效 

分 类 号：R734.2[医药卫生—肿瘤]