晚期非小细胞肺癌组织中BRCA1、RAP80的表达与化疗疗效的关系  

BRCA1 AND RAP80 EXPRESSIONS IN STAGE Ⅲ-IV NON-SMALL CELL LUNG CANCER AND THEIR RELATIONSHIP WITH CHEMOTHERAPY EFFECTS

作　　者：张贤兰[1] 黎少琴[1] 苏宁[1] 薛丽京[1] 刘燕[1] 

机构地区：[1]广州市胸科医院,广东广州510095

出　　处：《现代医院》2015年第6期11-13,16,共4页Modern Hospitals

基　　金：广东省科技计划项目(编号:粤科规划字[2012]145号)

摘　　要：目的研究人类乳腺癌易感基因(BRCA1)及受体相关蛋白80(RAP80)在晚期非小细胞肺癌(NSCLC)中的表达及其与化疗疗效的关系。方法应用免疫组织化学(IHC)方法检测62例经病理确诊为晚期NSCLC患者石蜡切片标本中BRCA1及RAP80蛋白表达的情况,分析其与吉西他滨联合顺铂(GP)方案化疗疗效的关系,同时分析BRCA1与RAP80表达水平的相关性。结果 BRCA1及RAP80蛋白表达在不同年龄、性别、吸烟史、PS评分、病理类型、TNM分期组中无明显差异;BRCA1和RAP80蛋白表达阴性组GP方案化疗有效率高于蛋白表达阳性组,两组比较差异有统计学意义(p<0.05);BRCA1与RAP80的表达呈正相关(γ=0.625,p<0.01)。结论 BRCA1及RAP80蛋白表达阳性与铂类耐药有关;BRCA1与RAP80的表达呈正相关,提示BRCA1通过RAP80参与DNA修复。Objective To analyze associations of gemcitabine - platinum chemotherapy effects with BRCA1 and RAPSO expressions in Ⅲ - IV non - small cell lung cancer （NSCLC）. Methods The immunohistochemical method was used to detect expression of BRCA1 and RAP80 in 62 patients with Ⅲ- IV NSCLC. Chi - square test was used to evaluate the association of chemotherapeutic effect with BRCA1 and RAPSO expressions. Spearman rela- tionship was conducted to evaluate the associations among expression of BRCA1 and RAPS0. Results In these 62 cases, positive expression of BRCA1 and RAPS0 had no correlation with age, gender, smoking, PS score, pathology and clinical stage. The patients with negative BRCA1 and RAP80 expression in In - IV NSCLC were more sensitive to gemcitabine -platinum chemotherapy compared with patients with positive BRCA1 and RAPS0 expression. There were statistical differences （p 〈 0. 05 ） ; The expression levels of BRCA1 and RAPSO were positive correlated （ r = 0. 625, p 〈 0.01 ）. Conclusion Positive BRCA1 and RAPSO expression are correlation with platinum resistance; The expression of BRCA1 and RAPS0 were positive correlated, which showed that BRCA1 repaired DNA through RAPS0 participation.

关 键 词：乳腺癌易感基因1 受体相关蛋白80非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]