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作 者:谢文林[1] 连家燕[1] 刘俊峰[1] 梁英杰[1] 唐刚华[2] 李智[1]
机构地区:[1]中山大学附属第一医院病理科,广东广州510080 [2]中山大学附属第一医院核医学科,广东广州510080
出 处:《临床医学工程》2015年第6期713-715,共3页Clinical Medicine & Engineering
基 金:国家自然科学基金项目(项目编号:81371584)
摘 要:目的探讨TRIM29在前列腺良恶性病变中的表达及鉴别诊断的意义。方法用免疫组化法对比68例前列腺癌、7例前列腺上皮内瘤(PIN)及56例良性前列腺增生组织中TRIM29表达情况,以34βE12表达情况为对照。结果 TRIM29在68例前列腺癌中均不表达,而在7例前列腺上皮内瘤(PIN)及56例良性前列腺增生中表达均为阳性,与34βE12表达情况一致。结论 TRIM29可以作为前列腺病变基底细胞的特异性标记物之一。Objective To investigate the expression and diagnostic value of TRIM29 in benign and malignant prostatic lesions.Methods 68 patients with prostatic cancer and 7 patients with prostatic intraepithelial neoplasia and 56 patients with benign prostatic hyperplasia were collected, the expression of TRIM29 and 34βE12 in tissue were detected by immunohistochemical staining and were evaluated and analyzed. Results The TRIM29 was not expressed in prostate cancer(68 cases), but it was expressed in benign prostatic hyperplasia(7 cases) and prostatic intraepithelial neoplasia(56 cases). The expression of TRIM29 in prostatic cancer, prostatic intraepithelial neoplasia and benign prostatic hyperplasia was the same as the expression of 34βE12. Conclusions TRIM29 may serve as a specific marker on the diagnosis of prostate basal cell lesions.
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