同型半胱氨酸水平与颈动脉斑块、脑动脉狭窄及脑动脉微栓子的关系  

Correlation Between Homocysteine Levels and Cerebral Arterial Stenosis, Carotid Plaque and Microembolus Signal

作　　者：罗政[1] 朱飞奇[1] 

机构地区：[1]粤北人民医院神经内科,广东韶关512000

出　　处：《临床医学工程》2015年第6期775-776,共2页Clinical Medicine & Engineering

摘　　要：目的评价同型半胱氨酸水平与脑动脉狭窄、微栓子(MES)及颈动脉斑块的关系。方法将370例门诊及住院患者根据Hcy水平分组,Hcy<10μmol/L为对照组(220例),10μmol/L≤Hcy≤15μmol/L为实验组1(90例),Hcy>15μmol/L为实验组2(60例)。所有患者均予以TCD、颈动脉彩超检测脑动脉MES、狭窄程度及颈动脉斑块,测定患者血TG、TC、LDL-C、HDL-C、UA、FBG、h CRP、ESR水平。结果实验组MES、脑动脉狭窄、颈动脉斑块发生率均高于对照组,Hcy、TG、TC、ESR、UA、FBG、LDL-C、h CRP均高于对照组,HDL-C低于对照组(P<0.05)。Hcy与MES、TC、TG、h CRP、UA、ESR、LDL-C存在正相关,与HDL-C存在负相关(P<0.05)。结论高Hcy与颈动脉斑块形成、脑动脉狭窄及MES有明显的正相关,是脑血管疾病的重要的危险因素。Objective To evaluate the relationship between homocysteine（Hcy） levels and carotid plaque, cerebral arterial stenosis and microembolus signal（MES）. Methods 370 cases of outpatients and inpatients were divided into three groups according to the Hcy levels, patients whose Hcy〈 10 μmol/L were set as control group（220 cases）, patients whose Hcy ≥10 μmol/L and ≤15 μmol/L were set as experimental group 1（90 cases）, patients whose Hcy〉 15 μmol/L were set as experimental group 2（60 cases）. The carotid plaque, cerebral arterial stenosis and MES were detected by TCD and color ultrasonography, the levels of serum TG, TC, LDL-C, HDL-C, UA, FBG, h CRP and ESR were measured. Results The incidence of MES, carotid plaque and cerebral arterial stenosis of the experimental group（1 and 2）were higher than that of the control group, the levels of Hcy, TG, TC, ESR, UA, FBG, LDL-C, h CRP of experimental group（1 and 2） were higher than those of the control group, the level of HDL-C was lower than that of the control group（both P〈0.05）. Hcy was positively associated with MES, TC, TG, h CRP, UA, ESR and LDL-C, negatively associated with HDL-C（P〈0.05）. Conclusions High Hcy has positive correlation with MES, carotid plaque and cerebral arterial stenosis, which is a risk factor of cerebrovascular disease.

关 键 词：同型半胱氨酸 脑动脉微栓子 脑动脉狭窄 颈动脉斑块 

分 类 号：R743[医药卫生—神经病学与精神病学]