^(18)F-FDGPET/CT在评价宫颈癌腹主动脉旁淋巴结转移中的价值  

Evaluation of ^(18)F-FDG PET/CT for the paraaortic nodal spread in patients with cervical carcinoma

作　　者：葛海云[1] 周俊东[1] 吴锦昌[1] 

机构地区：[1]南京医科大学附属苏州医院妇产科,苏州215002

出　　处：《南通大学学报（医学版）》2015年第3期202-204,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的 :评价18F-氟脱氧葡萄糖正电子发射断层显像/X线计算机断层扫描(Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography,18F-FDG PET/CT)显像在宫颈癌患者腹主动脉旁淋巴结转移判断中的价值。方法:回顾性分析2005年1月—2012年12月本院收治的宫颈癌患者26例,年龄29~62岁,平均48.1岁,所有患者均经术后宫颈活检证实,均在18F-FDG PET/CT检查后行腹腔镜腹主动脉旁淋巴结清扫。以术后病理结果为金标准,计算18F-FDG PET/CT诊断的敏感性、特异性、阳性预测值及阴性预测值。结果:26例宫颈癌患者中9例(34.6%)经病理证实发生腹主动脉旁淋巴结转移,其中2例(11.1%)患者为18F-FDG PET/CT阴性结果(假阴性),1例(12.5%)18F-FDG PET/CT显像为阳性结果病理证实为阴性结果(假阳性)。18F-FDG PET/CT显像诊断宫颈癌腹主动脉旁淋巴结转移的敏感性、特异性、阳性预测值及阴性预测值分别为77.7%、94.1%、87.5%及88.9%。结论:18F-FDG PET/CT显像在宫颈癌患者腹主动脉旁淋巴结转移的判断中具有较高的临床价值。Objective： To evaluate the accuracy of Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography（18F-FDG PET/CT） for detecting paraaortic lymph node spread in patients with cervical carcinoma. Methods： 26 patients with cervical cancer were retrospectively analyzed（age 29-62, mean age 48.1） from January 2005 to December 2012. All patients were confirmed with cervical biopsy. All patients with cervical carcinoma were submitted to a laparoscopic infrarenal paraaortic lymph node dissection after 18F-FDG PET/CT evaluation. Based on pathologic results as gold standard, sensitivity, specificity, and positive and negative predictive values of 18F-FDG PET/CT were calculated. Results： A total of 26 patients underwent a laparoscopic infrarenal paraaortic lymphadenectomy. Nine patients（34.6%） had pathologically proven paraaortic lymph node metastases. Among them, 2（11.1%） had negative 18F-FDG PET/CT （false negatives）. Furthermore, 1 positive FDG-PET patient was not affected after histologic analysis（12.5%false positives）. Sensitivity, specificity, positive negative predictive value of the 18F-FDG PET/CT were 77.7%, 94.1%, 87.5%and 88.9%respectively, for the detection of paraaortic lymph node metastases. Conclusion：The imaging of 18F-FDG PET/CT had high accuracy for detecting paraaortic lymph node metastasis in patients with cervical carcinoma.

关 键 词：宫颈癌 腹主动脉旁淋巴结 氟脱氧葡萄糖 正电子发射断层显像/计算机断层扫描 

分 类 号：R737.33[医药卫生—肿瘤]