儿茶素治疗老年慢性心衰患者的临床疗效及其对脂联素、胰岛素样生长因子-1的影响研究  

Research of Adp and IGF-1 on elderly patients with chronic heart failure by catechin

作　　者：赵雅彬[1] 高洁[2] 王宝玉[1] 孙漾丽[3] 杨宁[1] 

机构地区：[1]郑州大学附属郑州中心医院急诊科,河南郑州450007 [2]郑州铁路职业技术学院药学系,河南郑州450052 [3]郑州大学附属郑州中心医院心内科,河南郑州450007

出　　处：《中国生化药物杂志》2015年第4期126-128,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的分析脂联素、胰岛素样生长因子-1在老年慢心衰中的作用。方法 92例高龄慢性心力衰竭患者入组,根据就诊顺序分为2组,46例对照组,予强心、利尿、扩血管、降压常规对症治疗;实验组46例,在常规治疗的基础上加用儿茶素,50mg/kg口服,1天1次。2周为一个疗程,治疗1个疗程;比较治疗前后患者脂联素(Adp)、胰岛素样生长因子-1(IGF-1)、脑钠肽(BNP)、左室舒张末期内径(LVEDD)、左室收缩末内径(LVESD)、左心室射血分数(LVEF)。结果治疗后,观察组总有效率为93.48%;对照组总有效率为76.09%。观察组总有效率显著高于对照组(χ2=5.39,P<0.05)。经治疗两组患者BNP、Adp水平下降,IGF-1水平上升,与对照组比较,实验组BNP、Adp水平较低,IGF-1水平较高P<0.05。实验组LVEDD及LVESD较低,LVEF较高,P<0.05。结论儿茶素能够下调患者脂联素,升高胰岛素样生长因子-1,改善心衰程度,值得临床推广应用。Objective To analysis the role of adiponectin, insulin like growth factor -1 in elderly chronic heart failure.Methods 92 elderly patients with chronic heart failure were selected and divided into control group and experiment group.46 cases of the control group were treated with conventional treatment including strong heart, diuresis, vasodilator,lowering blood pressure, the experimental group was on the basis of routine treatment with catechin, 50 mg/kg orally, 1 times a day.2 weeks as a course, 1 course of treatment.Adiponectin, insulin like growth factor -1,BNP,LVEDD, LVESD and LVEF were compared before and after treatment.Results After treatment, the total effective rate of observation group was 93.48%, the control group total effective rate was 76.09%.The total effective rate of observation group was significantly higher than that of the control group （χ2 =5.39, P 〈0.05 ）.After treatment, BNP, Adp in two groups decreased, IGF-1 increased, compared with control group, BNP, Adp level of the experiment group were lower, IGF-1 was higher（P〈0.05）,and LVEDD and LVESD of the experiment were lower, LVEF was higher, （P〈0.05）. Conclusion Catechins can decrease the serum levels of adiponectin, elevate insulin like growth factor-1, improve the degree of heart failure, is worthy of clinical application.

关 键 词：儿茶素 高龄慢性心力衰竭 脂联素 胰岛素样生长因子-1 

分 类 号：R541[医药卫生—心血管疾病]