抗抑郁治疗对晚期非小细胞肺癌患者生活质量和化疗疗效的影响  

Antidepressant Therapy Improves Quality of Life and Chemotherapeutic Efficacy in Patients with Advanced Non-Small-Cell Lung Cancer

作　　者：陈颖兰[1] 刘震天[1] 万莉娟[1] 邹俊韬[1] 

机构地区：[1]江西省肿瘤医院内二科,南昌330029

出　　处：《实用临床医学（江西）》2015年第4期9-11,共3页Practical Clinical Medicine

摘　　要：目的探讨晚期非小细胞肺癌患者常规化疗与常规化疗联合抗抑郁治疗生活质量、化疗疗效的差异。方法将符合纳入标准的39例患者按简单随机方法分为治疗组(19例)和对照组(20例),治疗组给予常规化疗加抗抑郁治疗,对照组仅给予常规化疗,所有患者在治疗前、中、后给予卡式评分及抑郁评估,采用Karnofsky功能状态量表(KPS)进行行为状态评估,采用Zung抑郁自评量表(SDS)进行抑郁评估,同时采用WHO实体瘤疗效评估标准进行化疗疗效评价。结果治疗组治疗中及治疗后的KPS评分高于对照组(P<0.05),且治疗组化疗疗效优于对照组(P<0.05)。结论抗抑郁治疗可提高晚期肺癌患者生活质量和化疗疗效。ABSTRACT:Objective To compare the effects of conventional chemotherapy and conventional chemotherapy combined with antidepressant therapy on the quality of life and chemotherapeutic efficacy in patients with advanced non-small-cell lung cancer(NSCLC).Methods Patients meet-ing inclusion criteria were randomly treated with conventional chemotherapy alone(control group) or in combination with antidepressant therapy(treatment group).Before,during and after treat-ment,the performance status,depression and chemotherapeutic efficacy were assessed using Karnofsky Performance Status Scale (KPS),Zung Self-Rating Depression Scale (SDS)and Re-sponse Evaluation Criteria in Solid Tumors(RECIST),respectively.Results Compared with con-trol group,KPS score was increased and chemotherapeutic efficacy was improved in treatment group during and after treatment(P<0.05).Conclusion Antidepressant therapy can improves the quality of life and chemotherapeutic efficacy in patients with advanced NSCLC.

关 键 词：抗抑郁治疗 非小细胞肺癌 生活质量 化疗疗效 

分 类 号：R734.2[医药卫生—肿瘤]