猫眼草化学成分研究  

Chemical Constituents of Euphorbia lunulata

作　　者：刘超[1] 孙会 王维婷[1] 孙金月[1] Mark A.Smith 

机构地区：[1]山东省农业科学院农产品研究所,山东济南250100 [2]山东诚创医药技术开发有限公司,山东济南250101 [3]National Research Council Canada, Saskatoon, SK, Canada

出　　处：《中药材》2015年第3期514-517,共4页Journal of Chinese Medicinal Materials

基　　金：山东省引进外国专家项目(鲁人社办发[2014]82号);山东省泰山学者海外特聘专家人才引进项目(tshw20120747)

摘　　要：目的:研究大戟科植物猫眼草的化学成分。方法:运用硅胶、Sephadex LH-20、MCI等色谱进行分离纯化,通过红外光谱、紫外光谱、质谱、核磁共振等现代波谱学方法进行结构鉴定。结果:从猫眼草乙酸乙酯和正丁醇部位中分离得到了12个化合物,分别鉴定为:3β-羟基-7β-甲氧基-5-豆甾烯(1)、3β,22β-二羟基-7β-甲氧基-5-豆甾烯(2)、灰绿曲霉酰胺(3)、2,5-二羟基-4-甲氧基菲(4)、对羟基苯甲酸(5)、3-甲氧基-4-羟基苯甲酸(6)、灯盏花苷C(7)、5,7,4'-三羟基双氢黄酮(8)、山柰酚(9)、槲皮素(10)、科罗索酸(11)、金合欢素(12)。结论:除化合物9、10外,其余化合物均为首次从该植物中分离得到。Objective： To investigate the chemical constituents in the ethanol extract from the whole plant of Euphorbia lunulata. Methods： The whole plant of Euphorbia lunulata was extracted by 95% ethanol,then partitioned by system solvents with different polarity. The ethyl acetate and n-butyl alcohol extracts were separated on silica gel,Sephadex LH-20,and MCI columns. The isolated compounds were determined by detailed analysis of their spectral data. Results： Twelve compounds were isolated and identified from the ethyl acetate and n-butyl alcohol extracts of Euphorbia lunulata and the structures were identified as 7β-methoxy-stigmast-5-ene-3β-ol（ 1）,7β-methoxy-stigmast-5-ene-3β,22β-diol（ 2）,asperglaucide（ 3）,moscatin（ 4）,p-hydroxybenzoic acid（ 5）,3-methoxy-4-hydroxy benzoic acid（ 6）,erigeside C（ 7）,5,7,4＇-trihydroxy flavanone（ 8）,kaempferol（ 9）,quercetin（ 10）,corosolic acid（ 11） and acacetin（ 12）. Conclusion： All compounds except for 9 and 10 are reported from this plant for the first time.

关 键 词：猫眼草 大戟科 豆甾烯 槲皮素 科罗索酸 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]