NSE、hs-CRP和D-二聚体联合检测诊断急性脑梗死的价值  

Detection of Neuron-specific Enolase,High-sensitive C-reactive Protein and D-dimer for the Diagnosis of Acute Cerebral Infarction

作　　者：祁俐[1] 

机构地区：[1]沈阳市红十字会医院,辽宁沈阳110013

出　　处：《航空航天医学杂志》2015年第6期674-675,共2页Journal of Aerospace medicine

摘　　要：目的 探讨血清神经元特异性烯醇化酶（NSE）、超敏C反应蛋白（hs-CRP）和D-二聚体（D-D）联合检测对急性脑梗死的临床诊断价值。方法 选择2014年2月~2014年10月收治的急性脑梗死患者120例,另外选择同期健康体检者120例作为对照组,对各组别血清NSE、hs-CRP和D-D水平进行测定,并对测定结果 进行统计学分析。结果 急性脑梗死组患者血清中NSE、hs-CRP和D-D水平均显著高于对照组,组间比较具有显著性差异（P〈0.05）;轻度组、中度组、重度组患者NSE、hs-CRP和D-D水平亦逐渐升高,组间比较差异均有统计学意义（P均〈0.05）。结论 血清NSE、hs-CRP和D-二聚体水平升高与脑梗死的发生有密切关系,是脑梗死的危险因素,联合检测有助于了解脑梗死的发生和病情变化,对脑梗死的预防、治疗和早期诊断有着积极的临床意义。Objective To investigate clinical value of serum neuron - specific enolase （ NSE）, high - sensitive C - reactive protein （hs - CRP） and D - dimer detection in the diagnosis of acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction and 120 healthy examinees were recruited from the Red Cross Hospital of She- nyang City from February 2014 to October 2014. Serum NSE, hs - CRP and D - dimer levels were measured in the two groups. The measurement results was statistically analyzed. Results The serum NSE, hs - CRP and D - dimer levels in the acute cerebral infarction patients were significantly higher than that in the control group （ P 〈 0. 05 ）. NSE, hs - CRP and D - dimer levels were all increased in the patients with mild, moderate and severe cerebral infarction, there were sig- nificant differences between groups （P 〈 0. 05）. Conclusions Increasing levels of serum NSE, hs - CRP and D - di- mer are closely related with the pathogenesis of cerebral infarction, and are regarded a risk factor for cerebral infarction, the combined detection helps to understand the occurrence and condition of cerebral infarction, and has a positive clinical significance in the cerebral infarction prevention, treatment and early diagnosis.

关 键 词：NSE HS-CRP D-二聚体 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]