阿霉素联合顺铂对骨肉瘤肺转移的疗效分析  

Observation on the Clinical Efficacy of Adriamycin Combined with Cisplatin for Postoperative Osteosarcoma Patients with Lung Metastasis

作　　者：陈华妹[1] 刘胜岗[1] 谈文斌 周丽华[1] 刘剑帆[2] 周辉[2] 

机构地区：[1]长沙市中心医院,湖南长沙410018 [2]中南大学湘雅医学院附属肿瘤医院,湖南长沙410013

出　　处：《肿瘤药学》2015年第3期226-229,共4页Anti-Tumor Pharmacy

基　　金：湖南省医药卫生科研计划课题项目资助(B2012-098)

摘　　要：目的探讨阿霉素联合顺铂对骨肉瘤肺转移的临床疗效和安全性。方法选取72例骨肉瘤术后肺转移患者,随机分为观察组和对照组。对照组仅接受顺铂化疗,观察组采用阿霉素联合顺铂化疗。治疗后,比较两组患者的临床疗效,生存情况和不良反应的发生情况,并检测和比较两组患者治疗前后血清TNF-α、IL-2水平。结果对照组的总有效率为66.7%,观察组为86.1%,较对照组显著升高(P<0.05);对照组与观察组的疾病控制率分别为78.8%、94.4%,观察组显著高于对照组(P<0.05);观察组2年和3年生存率分别为70.4%、41.7%,均显著高于对照组(P<0.05)。两组患者不良反应发生率的差异无统计学意义(P>0.05)。化疗后两组患者的血清TNF-α、IL-2水平均较化疗前明显升高(P<0.05),且观察组的TNF-α、IL-2水平均明显高于对照组(P<0.05)。结论阿霉素联合顺铂的双联化疗方案可能通过增强机体的细胞免疫功能提高骨肉瘤肺转移的疗效,且安全性高。Objective To explore the clinical efficacy and safety of adriamycin combined with cisplatin in treatment of postop- erative osteosarcoma patients with lung metastasis. Methods The selected 72 postoperative osteosarcoma patients with lung me- tastasis were divided randomly into observation group and control group. Patients in control group were treated only with cisplatin, while those in observation group were given adriamyein combined with cisplatin. Clinical curative effect, survival time, adverse reaction and serum levels of TNF- ot and IL-2 before and after treatment were compared between the two groups. Results The total effective rate of the observation group （86.1%） was higher than that of the control group （66.7%）, and so was the disease con- trol rate, which was 78.8% in control group but 94.4% in obselwation group （P〈 0.05）. Moreover, the 2-year and 3-year survival rates were respectively 0.4% and 41.7% in the observation group, both significandy higher than in the control group （P〈0.05）. No statistically significant difference in adverse reactions was found between the two groups （P〉0.05）. After chemotherapy, the levels of TNF-α and IL-2 were increased obviously in both groups as compared with before chemotherapy （P 〈 0.05）, and they were all significantly higher in observation group than in control group （P 〈 0.05）. Conclusion Adriamycin combined with cisplatin could have better clinical effects for osteosarcoma patients with lung metastasis through enhancing immunity function.

关 键 词：阿霉素 顺铂 骨肉瘤术后 肺转移 临床疗效 

分 类 号：R738.1[医药卫生—肿瘤]